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(R)-(-)-3-(dimethylamino)-3-phenyl-1-propanol is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 82769-74-2 Structure
  • Basic information

    1. Product Name: (R)-(-)-3-(dimethylamino)-3-phenyl-1-propanol
    2. Synonyms: (R)-(-)-3-(dimethylamino)-3-phenyl-1-propanol
    3. CAS NO:82769-74-2
    4. Molecular Formula:
    5. Molecular Weight: 179.262
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 82769-74-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (R)-(-)-3-(dimethylamino)-3-phenyl-1-propanol(CAS DataBase Reference)
    10. NIST Chemistry Reference: (R)-(-)-3-(dimethylamino)-3-phenyl-1-propanol(82769-74-2)
    11. EPA Substance Registry System: (R)-(-)-3-(dimethylamino)-3-phenyl-1-propanol(82769-74-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 82769-74-2(Hazardous Substances Data)

82769-74-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 82769-74-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,7,6 and 9 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 82769-74:
(7*8)+(6*2)+(5*7)+(4*6)+(3*9)+(2*7)+(1*4)=172
172 % 10 = 2
So 82769-74-2 is a valid CAS Registry Number.

82769-74-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (R)-(-)-3-(dimethylamino)-3-phenyl-1-propanol

1.2 Other means of identification

Product number -
Other names (2R)-2-[3,5-bis(trifluoromethyl)phenyl]-2-cyano-N-methyl-thiopropionamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:82769-74-2 SDS

82769-74-2Relevant articles and documents

Chiral Lewis Base-Catalyzed, Enantioselective Reduction of Unprotected β-Enamino Esters with Trichlorosilane

Ye, Jianheng,Wang, Chao,Chen, Lin,Wu, Xinjun,Zhou, Li,Sun, Jian

supporting information, p. 1042 - 1047 (2016/04/19)

Catalytic asymmetric reduction of N-unsubstituted β-enamino esters represents a major challenge for asymmetric catalysis. In this paper, the first organocatalytic system that could be used for the asymmetric hydrosilylation of N-unsubstituted β-enamino esters has been developed. Using N-tert-butylsulfinyl-L-proline-derived amides and L-pipecolinic acid-derived formamides as catalyst, a broad range of β-aryl- and β-alkyl-substituted free β-amino esters could be prepared with high yields and enantioselectivities. The practicality was illustrated by the gram-scale asymmetric synthesis of ethyl (R)-3-amino-3-phenylpropanoate and isopropyl (S)-3-amino-4-(2,3,5-trifluorophenyl)butanoate. The resulting product can be smoothly transformed to the FDA approved medicines dapoxetine and sitagliptin in a short synthetic route.

Carica papaya lipase catalysed resolution of β-amino esters for the highly enantioselective synthesis of (S)-dapoxetine

You, Pengyong,Qiu, Jian,Su, Erzheng,Wei, Dongzhi

, p. 557 - 565 (2013/03/13)

An efficient synthesis of the (S)-3-amino-3-phenylpropanoic acid enantiomer has been achieved by Carica papaya lipase (CPL) catalysed enantioselective alcoholysis of the corresponding racemic N-protected 2,2,2-trifluoroethyl esters in an organic solvent. A high enantioselectivity (E > 200) was achieved by two strategies that involved engineering of the substrates and optimization of the reaction conditions. Based on the resolution of a series of amino acids, it was found that the structure of the substrate has a profound effect on the CPL-catalysed resolution. The enantioselectivity and reaction rate were significantly enhanced by switching the conventional methyl ester to an activated trifluoroethyl ester. When considering steric effects, the substituted phenyl and amino groups should not both be large for the CPL-catalysed resolution. The mechanism of the CPL-catalysed enantioselective alcoholoysis of the amino acids is discussed to delineate the substrate requirements for CPL-catalysed resolution. Finally, the reaction was scaled up, and the products were separated and obtained in good yields (≥ 80 %). The (S)-3-amino-3- phenylpropanoic acid obtained was used as a key chiral intermediate in the synthesis of (S)-dapoxetine with very high enantiomeric excess (> 99 %). A carica papaya lipase catalysed resolution of N-protected β-phenylalanine esters has been developed. High enantioselectivity was achieved by two strategies that involved engineering of the substrates and optimization of the reaction conditions. After 50 % conversion, the products were separated and used as key chiral intermediates for the synthesis of (S)-dapoxetine with > 99 % ee. Copyright

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