82776-69-0Relevant articles and documents
Potential Acyl-transfer Agents. Reactions of N-Acyl-2-pyridinecarboxamides with Nucleophiles
Morkved, Eva H.,Cronyn, Marshall W.
, p. 381 - 388 (2007/10/02)
A fast reaction is obserwed between a series of N-acyl-2-pyridinecarboxamides and cyclopentylamine or pyrrolidine.Most of the acylamides react exclusively at the pyridine-2-carbonyl group.The selectivity of these reactions is explained by the reaction of the pyridine-nitrogen as a base towards the external nucleophile in a five-ring transition state.The acylamides undergo slow reactions with 4-methylaniline, methanol or water.Several reaction paths are observed with these less reactive nucleophiles.An intramolecular acyl group transfer prior to the reaction with an external nucleophile is indicated for three of the N-acylamides which have an N,N-dialkylamino substituent in the pyridine-4-position.Nucleophilic attack occurs predominantly at the N-acyl group of these three compounds which are moderately active acyl-transfer agents.
Studies of Substituted N-Benzoyl-2-pyridinecarboxamides. Reactions with Acyl Chlorides and Other Electrophiles
Moerkved, Eva H.
, p. 77 - 84 (2007/10/02)
N-Benzoyl-4-(4-morpholinyl)-2-pyridinecarboxamides react as nucleophiles towards benzoyl chloride to give adducts which are stabilized by further addition of one mol of water.The structure of these compounds is elucidated by chemical and spectroscopic met
