828-16-0Relevant academic research and scientific papers
AZO MEDIATORS
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Paragraph 0122; 0123; 0124; 0125, (2017/01/02)
Azo compounds are disclosed that do not form azoxy dimers and that do not have any reactive nitroso groups. Also disclosed are use of the azo compounds as mediators in optical and electrochemical diagnostic methods, as well as detection reagents, kits and test elements that include such azo compounds and that can be used in the diagnostic methods.
New NO-Donors with antithrombotic and vasodilating activities, part 17. Arylazoamidoximes and 3-arylazo-1,2,4-oxadiazol-5-ones
Rehse, Klaus,Bade, Stephan,Harsdorf, Angela,Clement, Bernd
, p. 392 - 398 (2007/10/03)
Seven arylazoamidoximes (3), six phenoxycarbonyl derivatives (4), and six 1,2,4-oxadiazol-5-ones (5) have been prepared and their structure and purity etablished by spectroscopy and elemental analysis. In the EI mass spectra ready elimination of NO from the title amidoximes was observed. A new addition reaction of 3a with hydrochloric acid to 4-chlorophenylhydroazoamidoxime 7 is described. The compounds were tested for nitric oxide dependent biological properties, i.e. platelet aggregation, antithrombotic effects, and decrease in blood pressure. In arterioles of rats 5/19 compounds inhibited the formation of thrombi with a laser beam by ≤20% 2 h after oral administration of 60 mg/kg. Among these are three amidoximes (3a, 3e, 3f), one phenoxycarbonyl derivative (4a), and one oxadiazolone (5a). With the 4-chlorophenylazoamidoxime 3c a long lasting (24 h) decrease of blood pressure in spontaneously hypertensive rats was observed. Microsomal fractions of rat liver oxidize arylazoamidoximes and generate nitric oxide (e.g. 3a and 3b). NO was measured by the oxyhemoglobin assay. The influence of SOD, pretreatment of the rats with dexamethasone, as well as kinetic parameters were determined. Type 3 compounds, therefore, are a new class of NO donors. Type 4 and 5 compounds function as their prodrugs.
UV AND IR SPECTRA OF SOME ARENEDIAZOCYANIDES AND THEIR RADICAL-ANIONS
Kachkurova, I. Ya.,Ashkinadze, L. D.,Shamsutdinova, M. Kh.,Kazitsyna, L. A.
, p. 1629 - 1634 (2007/10/02)
The UV and IR spectra of some arenediazocyanides and their radical-anions with the general formula p-X-C6H4N=NCN, where X=CH3O, CN, NO2, CNN=N, CNC6H4, NO2C6H4, CNN=NC6H4, NO2C6H4S, CNN=NC6H4O, CNN=NC6H4S, were studied.During radical formation long-wave absorption bands appear in the UV spectrum in the region of 600-700 nm.The frequencies of the absorption band for the nitrile group (Δν 80-95 cm-1) in the IR spectrum are shifted substantially.The integral intensities ACN increase by two orders of magnitude.The obtained experimental data show that during radical formation from the arenediazocyanides the additional electron is concentrated mainly at the diazocyanide group, and in the binuclear systems the effect of the anionic substituent N=NCN(1-) is not transmitted to the second benzene ring.It is suggested that the special features in the spectral characteristics of the arenediazocyanides and their radical-anions are due to the specific structural character of the azo group.
