828-73-9

Basic information

• Product Name: PENTAFLUOROPHENYLHYDRAZINE
• Synonyms: 1-(Pentafluorophenyl)hydrazine;(Perfluorophenyl)hydrazine;Perfluorophenylhydrazine, 1-Hydrazino-2,3,4,5,6-pentafluorobenzene;NSC 88334;PFPH;WLN: ZMR BF CF DF EF FF;1-(2,3,4,5,6-PENTAFLUOROPHENYL)HYDRAZINE;PENTAFLUOROPHENYLHYDRAZINE
• CAS NO: 828-73-9
• Molecular Formula: C₆H₃F₅N₂
• Molecular Weight: 198.09
• EINECS: 212-586-7
• Product Categories: Phenylhydrazine;Hydrazines;Nitrogen Compounds;Organic Building Blocks
• Mol File: 828-73-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 74-76 °C(lit.)
• Boiling Point: 117.6 °C at 760 mmHg
• Flash Point: 24.9 °C
• Appearance: beige to brown crystalline powder
• Density: 1.4980 (estimate)
• Storage Temp.: -20°C
• Solubility: Soluble in methanol.
• PKA: 4.05±0.40(Predicted)
• Sensitive: Air Sensitive
• BRN: 747800
• CAS DataBase Reference: PENTAFLUOROPHENYLHYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: PENTAFLUOROPHENYLHYDRAZINE(828-73-9)
• EPA Substance Registry System: PENTAFLUOROPHENYLHYDRAZINE(828-73-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-24/25
• RIDADR: 2811
• WGK Germany: 3
• RTECS: MV8325000
• HazardClass: IRRITANT
• Hazardous Substances Data: 828-73-9(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

Uses

Pentafluorophenylhydrazine used to determine the purity of N-tert-butyl-N-[1-diethylphosphono-(2,2-dimethylpropyl)]nitroxide (DEPN) using 1H NMR spectroscopy.

InChI:InChI=1/C6H3F5N2/c7-1-2(8)4(10)6(13-12)5(11)3(1)9/h13H,12H2

Upstream product

• 392-56-3 Hexafluorobenzene 
• 7803-57-8 hydrazine hydrate 
• 302-01-2 hydrazine 

Downstream Products

• 21231-38-9 3-(Pentafluorophenyl-hydrazono)-1,3-dihydro-indol-2-one 
• 50656-22-9 benzoyl chloride perfluorophenylhydrazone 
• 112086-92-7 N,N'-dibenzoylpentafluorophenylhydrazine 
• 76071-78-8 1,4-bis(perfluorophenyl)-3,6-diphenyl-1,4-dihydro-sym-tetrazine 
• 19005-60-8 pentafluoro(3,5-dimethylpyrazol-1-yl)benzene 
• 81226-79-1 N-[(E)-1-Methyl-3-phenyl-prop-2-en-(E)-ylidene]-N'-pentafluorophenyl-hydrazine 
• 172909-75-0 2,5-anhydro-D-mannose pentafluorophenylhydrazone 

Relevant articles and documents

Studies in fluorinated 1,3-diketones and related compounds. Part XVII. Synthesis and spectroscopic studies of some new 5-alkyl-3-fluoroaryl-1-pentafluoroaryl-pyrazoles and 2-amino-6-alkyl(perfluoroalkyl)-4-aryl pyrimidines

Six new 3-(4'-fluorophenyl)-1,5-trisubstituted pyrazoles have been synthesized from the appropriate fluorinated 1,3-diketones and pentafluorophenylhydrazine in the presence of absolute ethanol and hydrochloric acid, viz., 1-pentafluorophenyl-3-(4'-fluorophenyl)-5-methylpyrazole, 1-pentafluorophenyl-3-(4'-fluorophenyl-5-trifluoromethylpyrazole, 5-ethyl-1-pentafluorophenyl-3-(4'-fluorophenyl) pyrazole, 5-(pentafluoroethyl)-1-pentafluorophenyl-3-(4'-fluorophenyl) pyrazole, 1-pentafluorophenyl-3-(4'-fluorophenyl 5-n-propylpyrazole and 5-(heptafluoropropyl)-1-pentafluorophenyl-3-(4'-fluorophenyl) pyrazole.In addition, six new 2-amino-4-(4'-fluorophenyl)-6-alkyl(perfluoroalkyl)-trisubstituted pyrimidines have been prepared from the same diketones and guanidine carbonate in the presence of hydrochloric acid using absolute ethanol as a solvent, viz., 2-amino-4-(4'-fluorophenyl)-6-methylpyrimidine., 2-amino-4-(4'-fluorophenyl)-6-trifluoromethylpyrimidine, 2-amino-6-ethyl-4-(4'-fluorophenyl)pyrimidine, 2-amino-6-pentafluoroethyl-4-(4'-fluorophenyl)pyrimidine, 2-amino-4-(4'-fluorophenyl)-6-n-propylpyrimidine and 2-amino-6-(heptafluoropropyl)-4-(4'-fluorophenyl)pyrimidine.All new fluorinated pyrazoles as well as pyrimidines have been characterized by elemental analyses as well as spectral studies.

Facile Synthesis of Fluorine containing 1,3,5-triarylpyrazoles and 3,5-Diarylisoxazoles

Fluorine containing 1,3-diarylchalchones on condensation with pentafluorophenylhydrazine in absolute ethanol, afforded the corresponding 1,3,5-triarylpyrazoles and with hydroxyl amine hydrochloride in pyridine yielded 3,5-diarylisoxazoles.Fluorinated chalchones were synthesised by condensation of the appropriate acetophenones and aromatic aldehydes in aqueous ethanolic sodium hydroxide solution.All the compounds were characterised by their analytical and ir, 1H nmr, 19F nmr and mass spectral data.Mass fragmentation patterns of these compounds have also been discussed.

Studies in potential organo-fluorine antibacterial agents. Part 6: Synthesis and antibacterial activity of some new fluorine containing 1,3,4,5,7-pentasubstituted dipyrazolo[3,4-b;4,3-e]pyridines

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