82816-38-4

Upstream product

• 76-84-6 triphenylmethyl alcohol 
• 107-19-7 propargyl alcohol 
• 106-96-7 propargyl bromide 
• 76-83-5 trityl chloride 

Downstream Products

• 854248-28-5 (4,4,4-triphenyl-but-2-ynyl)-trityl ether 
• 144242-26-2 (Z)-3-O-(triphenylmethyl)-1-(trimethylsilyl)prop-1-en-3-ol 
• 1033055-85-4 C₃₁H₃₂O₂ 
• 1451054-00-4 C₂₂H₁₈N₂O₃ 
• 1451054-05-9 C₂₂H₂₀N₂O₃ 

Relevant academic research and scientific papers

Hypervalent Iodine Based Reversible Covalent Bond in Rotaxane Synthesis

Reversible covalent bonds play a significant role in achieving the high-yielding synthesis of mechanically interlocked molecules. Still, only a handful of such bonds have been successfully employed in synthetic procedures. Herein, we introduce a novel app

Cyclopropanation of Benzene Rings by Oxidatively Generated α-Oxo Gold Carbene: One-Pot Access to Tetrahydropyranone-Fused Cycloheptatrienes from Propargyl Benzyl Ethers

Cyclopropanations of benzene rings by oxidatively generated α-oxo gold carbenes are for the first time demonstrated in a Buchner reaction, in which readily available propargyl benzyl ethers are converted in one-pot to tetrahydropyranone-fused cycloheptatrienes via sequential oxidative gold catalysis and base-promoted isomerization. Additional examples of arene cyclopropanations without fragmentation of the cyclopropane ring are also realized. (Figure presented.).

2-ACYLAMINOTHIAZOLES FOR THE TREATMENT OF CANCER

The present invention relates to inhibitors of the oncogenic protein kinase ALK of formula (I) as herein described and pharmaceutical compositions thereof. The compounds of formula (I) are useful in the preparation of a medicament, in particular for the treatment of cancer.

Fused ring aziridines as a facile entry into triazole fused tricyclic and bicyclic heterocycles

The intramolecular dipolar cycloaddition of an azide with an alkyne has provided a useful entry into triazole fused tricyclic heterocycles containing both the triazole ring and the oxazolidin-2-one ring system. The requisite azido-alkynes have been prepared via a two-step sequence from fused ring aziridines. A series of 6-12 membered rings containing both the oxazolidinone and triazole rings have been prepared. These ring systems have been designed as conformationally restrained analogs of RNA-binding oxazolidinones. The Royal Society of Chemistry 2012.

A convergent approach toward the C1-C11 subunit of phoslactomycins and formal synthesis of phoslactomycin b

The preparation of the C1-C11 subunit of phoslactomycins, and a formal synthesis of phoslactomycin B, were achieved by a convergent strategy involving the chelation-controlled addition of an alkynyl Grignard reagent to an α-alkoxy ketone. Catalytic enanti

Tris(pentafluorophenyl)borane: a mild and efficient catalyst for the chemoselective tritylation of alcohols

An efficient acid-catalyzed protection of alcohols as trityl ethers is described using triphenylmethanol in the presence of tris(pentafluorophenyl)borane (3 mol %) in dichloromethane at room temperature. The chemoselectivity of this protocol is demonstrat

Synthesis of Four Stereoisomeric Tetrose Derivatives from Propargyl Alcohol. One-carbon Homologation of Vinylsilanes via α,β-Epoxy Silanes

Silicon-mediated synthesis of stereomeric tetroses 1, 2, 3, and 4, from propargyl alcohol is described.An allylic alcohol bearing the trimethylsilyl group in the γ position, rac-9b, was subjected to the Sharpless kinetic resolution to give (2S)-9b and the

The Total Synthesis of (+/-)-cis-Trikentrin B via Allene Intramolecular Cycloaddition

The first total synthesis of (+/-)-cis-trikentrin B (1) based on a new indole synthesis via the intramolecular Diels-Alder reaction of 1,2,3-trisubstituted allenic dienamide (8) is described.

REACTION OF 1-PROPYN-3-OL WITH ALCOHOLS

The reaction of propargyl alcohol with primary alcohols in the presence of metal complex catalysts leads to 2,5-dialkoxy-2,5-dimethyl-1,4-dioxanes.In contrast to primary alcohols, condensation to form 3-alkoxy- or 3-aryloxypyronines is the first step of the reaction of trimethyl-, dimethylethyl-, and triphenylcarbinols with propargyl alcohol.In the case of alkylcarbinols, these pyronines undergo hydration of the triple bond and cleavage of alkoxyacetones.One of the products of the reaction of propargyl alcohol with trimethyl- and dimethylcarbinols is 2,5-di(2-propynoxy)-2,5-dimethyl-1,4-dioxane.The same product was isolated upon heating propargyl alcohol in ether in the presence of HgO + (C2H5)2O.BF3.