82819-49-6Relevant academic research and scientific papers
DIASTEREOSELECTIVITY IN THE DIRECTED ALDOL CONDENSATION OF 2-TRIMETHYLSILOXYFURAN WITH ALDEHYDES. A STEREODIVERGENT ROUTE TO THREO AND ERYTHRO δ-HYDROXY-γ-LACTONES
Jefford, Charles W.,Jaggi, Danielle,Boukouvalas, John
, p. 4037 - 4040 (2007/10/02)
Threo and erythro-δ-hydroxy-4a,β-unsaturated γ-lactones are obtained with useful diastereoselection by condensing 2-trimethylsiloxyfuran and aldehydes by variying the reaction conditions.A stereomechanistic rationale is presented together with a practical two-step synthesis of the threo and erythro 5-hydroxy-4-decanolides (L-factors).
