828291-16-3

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 583-60-8 2-Methylcyclohexanone 

Downstream Products

• 184035-04-9 (1R,2R)-1-Amino-2-methyl-cyclohexanecarboxylic acid amide 
• 184035-03-8 (1R,2S)-1-Amino-2-methyl-cyclohexanecarboxylic acid amide 
• 184035-01-6 (1S,2R)-1-Amino-2-methyl-cyclohexanecarboxylic acid amide 
• 184035-02-7 (1S,2S)-1-Amino-2-methyl-cyclohexanecarboxylic acid amide 
• 184035-12-9 (1S,2R)-2-Methyl-1-((R)-1-phenyl-ethylamino)-cyclohexanecarboxylic acid amide 
• 184035-13-0 (1S,2S)-2-Methyl-1-((R)-1-phenyl-ethylamino)-cyclohexanecarboxylic acid amide 
• 184035-11-8 (1R,2R)-2-Methyl-1-((R)-1-phenyl-ethylamino)-cyclohexanecarboxylic acid amide 
• 184035-09-4 (1R,2S)-2-Methyl-1-((R)-1-phenyl-ethylamino)-cyclohexanecarboxylic acid amide 
• 53068-89-6 (S)-3-(1-methyl-2-oxocyclohexyl)-propionic acid methyl ester 
• 1372790-21-0 ethyl (S)-5-(1-methyl-2-oxocyclohexyl)pent-2-ynoate 

Relevant academic research and scientific papers

THE ASYMMETRIC MICHAEL PROCESS INVOLVING CHIRAL IMINES: THE DIASTEREOFACIAL DIFFERENTIATION ASPECT

A mechanism for the diastereofacial differentiation in the title reaction is proposed on the basis of the variation of the chiral auxiliary amines and of the examination of the crystal structure of enamino-ester 15.

Stereoselective Michael additions on α-aminoacrylates as the key step to an l-Oic analogue bearing a quaternary stereocenter

A novel, highly stereoselective route for pharmaceutically relevant octahydroindole-2-carboxylates bearing a quaternary stereocenter has been developed. The key chiral intermediates 3 have been prepared in good yields and enantiomeric excesses up to 98%. A broad substrate range has been tolerated under the reaction conditions.

Intramolecular reductive ketone-alkynoate coupling reaction promoted by (η2-propene)titanium

Intramolecular reductive coupling of cycloalkanones tethered to alkynoates in the presence of (η2-propene)titanium was successfully performed to provide hydroxy-esters in a diastereoselective manner. Subsequent lactonization afforded angularly

Pyrrolopyrazinyl Urea Kinase Inhibitors

The present invention relates to the use of novel pyrrolopyrazinyl urea derivatives of Formula I, wherein the variables R1, R2, R3, R4, and R5 are defined as described herein, which inhibit JAK and are useful for the treatment of auto-immune and inflammatory diseases.

Asymmetric strecker synthesis of the four α-quaternary 1-amino-2-methylcyclohexanecarboxylic acids

The synthesis of the four 1-amino-2-methylcyclohexanecarboxylic acids 13, 14, 15, and 16 from diastereomeric mixtures of the α-amino nitriles 1-4 by successive application of conc. H2SO4, Pd/C H2, and conc. HCl is describe

ASYMMETRIC SYNTHESIS OF CIS-2-SUBSTITUTED CYCLOHEXANAMINES WITH HIGHT OPTICAL PURITY

Asymmetric reductive amination of racemic 2-substituted cyclohexanones (R= methyl, ethyl, phenyl, benzyl) using optically active 1-phenyl-ethylamines yields optically active cis-cyclohexanamines.