828300-90-9

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 828300-89-6 trifluoromethanesulfonic acid 1-(4-chlorophthalazin-1-yl)-naphthalen-2-yl ester 
• 4752-10-7 1,4-dichlorophthalazine 
• 597552-98-2 1-(4-chlorophthalazin-1-yl)-naphthalen-2-ol 

Downstream Products

• 828927-96-4 (S)-4-[2-(diphenylphosphine)-1-naphthalene]-N-[(R)-1-phenethyl]-1-phthalazine 
• 828927-96-4 (R,Rax)-[4-(2-diphenylphosphanylnaphthalen-1-yl)-phthalazin-1-yl]-(1-phenylethyl)-amine 
• 828927-96-4 (S)-PINAP 
• 828927-96-4 (R,P)-[4-(2-diphenylphosphanylnaphthalen-1-yl)phthalazin-1-yl]-(1-phenylethyl)amine 
• 828927-96-4 (R,M)-[4-(2-diphenylphosphanylnaphthalen-1-yl)phthalazin-1-yl]-(1-phenylethyl)amine 

Relevant academic research and scientific papers

PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE AMINES

Salts of optically active [4-(2-diphenylphosphanylnaphthalen-1-yl)phthalazin-1-yl]-(1-phenylethyl)amines represented by the formulas (1) to (4) with an optically active organic sulfonic acid, and a production method thereof.

Readily available biaryl P,N ligands for asymmetric catalysis

A short and modular synthesis of novel P,N ligands (pinap; see scheme; X = O or NH) is presented. A covalently bound chiral group allows the separation of the atropisomeric diastereomers, thus avoiding resolution involving chiral Pd-amine complexes. The utility of the ligands is demonstrated for three reactions catalyzed by different transition metals; in each case products are obtained with high enantiomeric excess (up to 99% ee).