82832-95-9

Upstream product

• 22780-54-7 2-amino-3,4,5,6-tetrahydropyridine 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Downstream Products

• 126525-96-0 2-Oxo-9-[1-phenyl-meth-(E)-ylidene]-6,7,8,9-tetrahydro-2H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester 
• 126525-95-9 (S)-9-((R)-Hydroxy-phenyl-methyl)-2-oxo-6,7,8,9-tetrahydro-2H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Nitrogen Bridgehead Compounds. Part 19 (1). Synthesis of Polymethylenepyrimidin-4-ones

Reaction of five-, six-, seven-, and eight-membered cyclic amidines (1 n = 0-3) with diethyl ethoxymethylenemalonate (2) yields isomeric 2,3-polymethylene-4(3H)- and 1,2-polymethylene-4(1H)-pyrimidinones (3 and 4) respectively, n = 0-3).With 2-aminopyrroline the isomer ratio was dependent upon the reaction conditions.The structure of the isomers 3 and 4 was studied by uv, ir and 1H-nmr spectroscopy.Both isomers contain an active methylene group which can be deuterated.Deuteration was investigated with 1H-nmr spectroscopy.