82833-28-1Relevant academic research and scientific papers
BENZOPHENOXAZINE DERIVATIVES FOR DIAGNOSIS OF NEOPLASIA OR INFECTION
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Paragraph 0060-0061, (2019/10/29)
The present disclosure is related to the synthesis and applications of a benzo[a]phenoxazine. It displays good photophysical properties, such as high molar extinction coefficient, good fluorescence quantum yield and solubility in water. The present invent
Method for synthesizing Nitro-PAPS
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Paragraph 0006; 0007, (2018/10/19)
The invention discloses a method for synthesizing Nitro-PAPS. The chemical structural formula of the Nitro-PAPS is shown in the description. The Nitro-PAPS serves as commercialized hypersensitive colorimetric reagent for detecting Fe(II) in serum, and is also used for detecting zinc in the serum, has the advantages of high sensitivity, good accuracy, simple and stable reagent, small interference,rapid, simple and convenient operation and the like, and is widely used in biochemical detection. The price of the Nitro-PAPS is expensive, and the literature and patent reports for the synthesis method of the Nitro-PAPS are few, therefore, the invention provides a simple efficient synthesis method with high yield, mild reaction condition and very suitable for industrialized production. Accordingto the method, cheap m-aminophenol serves as a raw material, the m-aminophenol, bromopropane and 1,3-propane sultone are subjected to two-step nucleophilic substitution reaction, lastly, the m-aminophenol and diazonium salt of 2-amino-5-nitropyridine are coupled, and the Nitro-PAPS is synthesized by three steps with a high yield. The whole synthesis technology is simple and efficient, has low cost, and is an economically feasible industrialized production method.
Synthesis and photophysical studies of new benzo[a]phenoxazinium chlorides as potential antifungal agents
Leit?o, M. Inês P.S.,Raju, B. Rama,Naik, Sarala,Coutinho, Paulo J.G.,Sousa, Maria Jo?o,Gon?alves, M. Sameiro T.
supporting information, p. 3936 - 3941 (2016/08/09)
A set of four new benzo[a]phenoxazinium chlorides possessing ethyl, propyl, decyl and tetradecyl groups at the 9-amino function of the heterocycle along with a propyl group at the 5-amino position was efficiently synthesized. These compounds displayed fluorescence with maximum emission wavelengths of 673 and 685?nm, in anhydrous ethanol and water. All the benzo[a]phenoxazines were evaluated against the yeast Saccharomyces cerevisiae in a broth microdilution assay. It was found that their antifungal activity depended on the variation in the lengths of the aliphatic chains. The highest MIC activity of 1.56?μM was obtained for compound 7 comprising a di-alkylated propyl substituent at 9-amino position and a propyl chain at the 5-amino position of the heterocycle core.
