82843-14-9

Basic information

• Product Name: 3-ethyl-2-hydroxy-7,7-dimethyl-5-[(2-methylpropyl)amino]-6,7-dihydro-4H-thiopyrano[2,3-b]pyridin-4-one
• Synonyms: 3-Ethyl-2-hydroxy-5-(isobutylamino)-7,7-dimethyl-6,7-dihydro-4H-thiopyrano(2,3-b)pyridin-4-one; 3-Ethyl-2-hydroxy-5-(isobutylamino)-7,7-dimethyl-6,7-dihydro-4H-thiopyrano[2,3-b]pyridin-4-one
• CAS NO: 82843-14-9
• Molecular Formula: C₁₆H₂₄N₂O₂S
• Molecular Weight: 308.439
• Mol File: 82843-14-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 427.4°C at 760 mmHg
• Flash Point: 212.3°C
• Density: 1.22g/cm³
• Vapor Pressure: 4.27E-09mmHg at 25°C
• Refractive Index: 1.599
• CAS DataBase Reference: 3-ethyl-2-hydroxy-7,7-dimethyl-5-[(2-methylpropyl)amino]-6,7-dihydro-4H-thiopyrano[2,3-b]pyridin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ethyl-2-hydroxy-7,7-dimethyl-5-[(2-methylpropyl)amino]-6,7-dihydro-4H-thiopyrano[2,3-b]pyridin-4-one(82843-14-9)
• EPA Substance Registry System: 3-ethyl-2-hydroxy-7,7-dimethyl-5-[(2-methylpropyl)amino]-6,7-dihydro-4H-thiopyrano[2,3-b]pyridin-4-one(82843-14-9)

Safety Data

• Hazardous Substances Data: 82843-14-9(Hazardous Substances Data)

Upstream product

• 15781-72-3 bis(2,4,6-trichlorophenyl) ethylmalonate 
• 58913-40-9 4-isobutylamino-6,6-dimethyl-5,6-dihydro-1H-pyridine-2-thione 

Relevant articles and documents

Chemistry of 5-Alkylamino-4H-thiopyranopyridine-4-ones

4-Alkylaminopyridinethiones*HCl (1*HCl) react with bis-trichlorethylmalonate (3) predominantly to 5-alkylamino-4H-thiopyranopyridine-4-ones (6).With alcohols in the presence of acids at 25 deg C 6 undergoes an alcoholysis to the corresponding alkyl-3-(2-thioxo-3-pyridyl)propionates (9).On heating in dilute alkali 6 is hydrolysed via 4-alkylamino-2-thioxopyridylpropylketones (11) to the tautomers, 4-hydroxy-2-thioxopyridylpropylketone (12A) and 2-thioxo-3-(1-hydroxybutenyl)-4-piperidon (12B), resp.On refluxing with alkali the ethyl-pyridylpropionate 9a is cyclisized to the 1-alkyl-1,6-naphthyridine-2(1H)-one (4a), but boiling in ethanolic acid hydrolyses 9a via the pyridylpropionic acid 10 to 4-alkyl-aminopyridylpropylketone (11a).The latter can be transformed via the tautomers 12A, B and 2-methylthio-3-pyridylpropylketone (13) to the 4-hydroxy-3-butyrylpyridone (14A) and its tautomer, 3-(1-hydroxy-butenyl)-piperidine-2,4-diones (14B), resp.The structure of 14A, B is established by reaction of 4-isopropylamino-2(1H)-pyridone (2) with butanoylchloride to the 4-isopropylamino-3-butyrypyridone (15) and hydrolysis of 15 to the tautomers 14A, B. - Keywords: 4-Alkylamino-2(1H)pyridinethiones*HCl, reaction with bistrichlorphenyl-ethylmalonate; Alkyl-3(2-thioxo-3-pyridyl)propionates; 4-Hydroxy-3-butyrylpyridone; 4-Hydroxy-2-thioxopyridylpropylketone; Tautomerism