82859-75-4Relevant academic research and scientific papers
Harnessing the reactivity of Ortho-formyl-arylketones: Base-promoted regiospecific synthesis of functionalized isoquinolines
Mishra, Pawan K.,Verma, Shalini,Kumar, Manoj,Kumar, Ankit,Verma, Akhilesh K.
, p. 8278 - 8281 (2019/07/16)
An efficient and base-mediated one-pot regiospecific synthesis of structurally diversified isoquinolines and benzo[h] isoquinolines from easily accessible ortho-formyl-arylketones and aryl/(het)arylmethanamines has been described. Challenging 3-alkynyl/alkenyl isoquinolines and bis-isoquinolines were easily attained through this developed chemistry, which can be further used for various organic transformations. Operational simplicity, high atom-economy, broad substrate scope, functional group tolerance and applicability towards large scale synthesis are the advantageous features of this developed methodology.
Design, synthesis and in vitro antimalarial activity of an acylhydrazone library
Melnyk, Patricia,Leroux, Virginie,Sergheraert, Christian,Grellier, Philippe
, p. 31 - 35 (2007/10/03)
A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the
Synthesis of New Acylhydrazones as Iron-Chelating Compounds
Edward, John T.,Gauthier, Mario,Chubb, Francis L.,Ponka, Premysl
, p. 538 - 540 (2007/10/02)
Fourteen acylhydrazides have been condensed with three aromatic o-hydroxy aldehydes (pyridoxal, salicylaldehyde, and 2-hydroxy-1-naphthaldehyde) to give 42 acylhydrazones, of which 38 are new.These compounds complex iron and have shown varying abilities to promote the movement of iron across biological membranes.Their infrared and nuclear magnetic resonance spectra support the structures assigned to them.
