82883-89-4

Basic information

• Product Name: 5,10-bis(uracil-5-ylmethyl)<6-2H₁>tetrahydropteroylglutamic acid
• CAS NO: 82883-89-4
• Molecular Weight: 694.625
• Mol File: 82883-89-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5,10-bis(uracil-5-ylmethyl)<6-2H₁>tetrahydropteroylglutamic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5,10-bis(uracil-5-ylmethyl)<6-2H₁>tetrahydropteroylglutamic acid(82883-89-4)
• EPA Substance Registry System: 5,10-bis(uracil-5-ylmethyl)<6-2H₁>tetrahydropteroylglutamic acid(82883-89-4)

Safety Data

• Hazardous Substances Data: 82883-89-4(Hazardous Substances Data)

Upstream product

• 3590-48-5 5-chloromethyluracil 
• 4033-27-6 (S)-2-{4-[(2-Amino-4-oxo-3,4,7,8-tetrahydro-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid 

Relevant articles and documents

A Chemical Model for the Thymidylate Synthetase Catalysed Methylation of Deoxyuridine Monophosphate

In a study of a model for the reaction catalysed by the enzyme thymidylate synthetase, a compound previously thought to be the putative intermediate 5-(uracil-5-ylmethyl)tetrahydropteroylglutamic acid (4b) has been prepared and shown to be the 5,10-bis(uracil-5-ylmethyl) adduct (4c).The tetrahydrofolic acid adduct (4d) and its analogue have been prepared and have been shown to be thermally converted into thymine (5, R2=H).The reaction with deuteriated (4d) shows a high discrimination for the hydrogen at C-6 of the pteridine moiety which rearranges to the methyl group of the resultant thymine (5, R2=H).These findings parallel results found for the biochemical process very closely and possible mechanisms for the reaction are discussed.The compounds (4c) and (4d) are neither substrates nor inhibitors of thymidylate synthetase.