82884-46-6Relevant academic research and scientific papers
A Flexible and Efficient Synthesis of Methyl 4-Oxo-2-alkenoates
Reichelt, Ingrid,Reissig, Hans-Ulrich
, p. 820 - 827 (2007/10/02)
The title compounds E are obtained in good yield by low temperature ring cleavage of the easily available methyl 2-siloxycyclopropanecarboxylates C with bromine and subsequent elimination of hydrogen bromide.Due to the variability of C a high flexibility concerning substituents R1 - R4 in products E is guaranteed. 2-Alkyl- and 2-methylthio-substituted olefins are thus effectively synthesized.In several cases the initially formed methyl 2-bromo-4-oxoalkanoates F are stable enough to be isolated in high yield.
AN EFFICIENT AND HIGHLY FLEXIBLE SYNTHESIS OF α,β-UNSATURATED γ-OXOESTERS
Boehm, Ingrid,Schulz, Rick,Reissig, Hans-Ulrich
, p. 2013 - 2016 (2007/10/02)
Siloxy substituted methyl cyclopropanecarboxylates are cleaved by bromine to afford α-bromo-γ-oxoester and, after treatment with triethylamine, good yields of α,β-unsaturated γ-oxoesters.
