82892-95-3Relevant academic research and scientific papers
Direct, metal-free amination of heterocyclic amides/ureas with NH-heterocycles and N-substituted anilines in POCl3
Deng, Xiaohu,Roessler, Armin,Brdar, Ivana,Faessler, Roger,Wu, Jiejun,Sales, Zachary S.,Mani, Neelakandha S.
experimental part, p. 8262 - 8269 (2011/12/04)
A POCl3-mediated, direct amination reaction of heterocyclic amides/ureas with NH-heterocycles or N-substituted anilines is described. Compared to the existing methods, this operationally simple protocol provides unique reactivity and functional
Synthesis and cytoprotective antiulcer activity of 2- or 4-(1H-pyrazol- 1-yl)pyrimidine derivatives related to mepirizole and dulcerozine
Ikeda, Masazumi,Maruyama, Kazumi,Nobuhara, Youichi,Yamada, Toshihiro,Okabe, Susumu
, p. 1700 - 1706 (2007/10/03)
(1H-Pyrazol-1-yl)-, (1H-imidazol-1-yl)-, and (1H-1,2,4-triazol-1- yl)pyrimidines were prepared and evaluated for cytoprotective antiulcer activity. Among them, 4-methoxy-6-methyl-2-(1H-pyrazol-1-yl)pyrimidine (18) showed potent inhibition of the HCl-ethanol-induced and water-immersion stress-induced ulcers in rats, as well as low acute toxicity.
SYNTHESES OF NEW PYRAZOLE-DERIVED CHELATING LIGANDS
Steel, Peter J.,Constable, Edwin C.
, p. 1601 - 1611 (2007/10/02)
The preparations and spectral data for nine new N,N'-chelating ligands (5)-(13), each consisting of a pyrazole group N-linked to an azine or azole, are described.
