828926-06-3

Basic information

• Product Name: (R)-5-AMINO-5,6,7,8-TETRAHYDRONAPHTHALENE-2-CARBONITRILE
• Synonyms: (R)-5-AMINO-5,6,7,8-TETRAHYDRONAPHTHALENE-2-CARBONITRILE;(R)-5-aMino-5,6,7,8-tetrahydronaphthalene-2-carbonitrile HCl;(R)-5-Amino-5,6,7,8-tetrahydronaphthalene-2-carbonitrile hydrochloride
• CAS NO: 828926-06-3
• Molecular Formula: C₁₁H₁₂N₂
• Molecular Weight: 172.23
• Mol File: 828926-06-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-5-AMINO-5,6,7,8-TETRAHYDRONAPHTHALENE-2-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-AMINO-5,6,7,8-TETRAHYDRONAPHTHALENE-2-CARBONITRILE(828926-06-3)
• EPA Substance Registry System: (R)-5-AMINO-5,6,7,8-TETRAHYDRONAPHTHALENE-2-CARBONITRILE(828926-06-3)

Safety Data

• Hazardous Substances Data: 828926-06-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
(R)-5-AMINO-5,6,7,8-TETRAHYDRONAPHTHALENE-2-CARBONITRILE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
In the chemical research industry, (R)-5-AMINO-5,6,7,8-TETRAHYDRONAPHTHALENE-2-CARBONITRILE serves as a valuable compound for studying its reactivity and potential use in creating new chemical entities with diverse applications.
Used in Drug Synthesis:
(R)-5-AMINO-5,6,7,8-TETRAHYDRONAPHTHALENE-2-CARBONITRILE is used as a building block in the creation of new drug molecules, contributing to the development of innovative treatments for various medical conditions.
Used in Medicinal Chemistry:
(R)-5-AMINO-5,6,7,8-TETRAHYDRONAPHTHALENE-2-CARBONITRILE is utilized in medicinal chemistry as a starting material for the design and synthesis of new therapeutic agents, potentially leading to the discovery of novel medicines with improved efficacy and safety profiles.
Used in Biological Activity Studies:
(R)-5-AMINO-5,6,7,8-TETRAHYDRONAPHTHALENE-2-CARBONITRILE is employed in research aimed at understanding its biological activity, which may reveal new insights into its potential as a therapeutic agent or a tool for studying biological processes.

Upstream product

• 1056057-47-6 5(R)-azido-5,6,7,8-tetrahydronaphthalene-2-carbonitrile 
• 321330-31-8 5-amino-5,6,7,8-tetrahydronaphthalene-2-carbonitrile 

Downstream Products

• 828926-07-4 5(R)-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile 

Relevant articles and documents

Mapping the substrate scope of monoamine oxidase (MAO-N) as a synthetic tool for the enantioselective synthesis of chiral amines

A library of 132 racemic chiral amines (α-substituted methylbenzylamines, benzhydrylamines, 1,2,3,4-tetrahydronaphthylamines (THNs), indanylamines, allylic and homoallylic amines, propargyl amines) was screened against the most versatile monoamine oxidase (MAO-N) variants D5, D9 and D11. MAO-N D9 exhibited the highest activity for most substrates and was applied to the deracemisation of a comprehensive set of selected primary amines. In all cases, excellent enantioselectivity was achieved (e.e. >99%) with moderate to good yields (55–80%). Conditions for the deracemisation of primary amines using a MAO-N/borane system were further optimised using THN as a template addressing substrate load, nature of the enzyme preparation, buffer systems, borane sources, and organic co-solvents.

Piperazine derivatives and methods of use

Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.