828930-34-3

Upstream product

• 458566-99-9 4,5-dimethyl-2-(trimethylsilyl)phenyl triflate 
• 106-45-6 para-thiocresol 
• 42927-46-8 tetra-O-acetyl-D-xylofuranose 

Downstream Products

• 828930-45-6 p-tolyl 2,3-anhydro-1-thio-β-D-ribofuranoside 
• 527680-93-9 p-tolyl 2,3-anhydro-5-O-benzoyl-1-thio-β-D-ribofuranoside 

Relevant academic research and scientific papers

Transition-metal-free synthesis of aryl 1-thioglycosides with arynes at room temperature

A mild, convenient and transition-metal-free protocol for the synthesis of aryl 1-thioglycosides is presentedviaarynes generatedin situcombined with glycosyl thiols in the presence of TBAF(tBuOH)4. The methodology provides a general and efficient way to prepare a series of functionalized thioglycosides in good to excellent yields with a perfect control of the anomeric configuration at room temperature. In addition, the reaction conditions tolerate a variety of the pentoses and hexoses, and the reaction also performs smoothly on protected monosaccharides and disaccharides.

An efficient route to thioglycosides with the 2,3-anhydro-D-ribo stereochemistry

An improved route for the synthesis of p-tolyl 2,3-anhydro-5-O-benzoyl-1- thio-β-d-ribofuranoside and its α anomer, which are important intermediates in the synthesis of α- and β-d-arabinofuranosides, has been developed. The products are obtained in six steps from d-xylose in 39% overall yield.