82894-98-2

Usage

Chemical Properties

Off-white solid

InChI:InChI=1/C8H5N3O2S/c12-11(13)7-3-1-6(2-4-7)8-5-14-10-9-8/h1-5H

Upstream product

• 1402672-05-2 C₁₇H₂₄N₅O₄S⁽¹⁺⁾*CF₃O₃S^(1-) 
• 130747-33-0 5-azidomethyl-4-(p-nitrophenyl)-1,2,3-thiadiazole 
• 130747-30-7 5-bromomethyl-4-(p-nitrophenyl)-1,2,3-thiadiazole 
• 130747-23-8 5-Methyl-4-(4-nitro-phenyl)-[1,2,3]thiadiazole 
• 120445-79-6 C₉H₁₀N₄O₃ 
• 130747-35-2 4-(p-nitrophenyl)-1,2,3-thiadiazole-5-carbaldehyde 

Downstream Products

• 140241-21-0 2-phenylimino-4-p-nitrophenyl-1,3-thiaselenole 

Relevant academic research and scientific papers

Perylenequinonoid-Catalyzed [4 + 1] and [4 + 2] Annulations of Azoalkenes: Photocatalytic Access to 1,2,3-Thiadiazole/1,4,5,6-Tetrahydropyridazine Derivatives

Nitrogen-containing heterocycles are especially considered "privileged" structural scaffolds for the development of new drugs. However, traditional methods of organic synthesis are mainly based on thermal cycloaddition reaction; thus, the exploration of n

Ionic liquid as soluble support for synthesis of 1,2,3-thiadiazoles and 1,2,3-selenadiazoles

A convenient synthesis of 1,2,3-thiadiazoles and 1,2,3-selenadiazoles was achieved using an ionic liquid as a novel soluble support. Ionic liquid-supported sulfonyl hydrazine was synthesized and reacted with a number of ketones to afford the corresponding ionic liquid-supported hydrazones that were converted to 1,2,3-thiadiazoles in the presence of thionyl chloride. The reaction of ionic liquid-supported hydrazones with selenium dioxide in acetonitrile afforded 1,2,3-selenadiazoles. The advantages of this methodology were the ease of workup, simple reaction conditions, and high purity.

Synthesis of 1,2,3-Thiadiazole-5-carbaldehydes and their Conversion into 6aλ4-Thia-1,2,5,6-tetraazapentalenes

A convenient method for the synthesis of the virtually unknown 1,2,3-thiadiazole-5-carbaldehydes consists in monobromination of the 5-methyl derivatives, followed by treatment with sodium azide and decomposition in concentrated sulfuric acid (6 -> 7 -> 9

Kinetics and Mechanism of the Reaction of Thionyl Chloride with Substituted Acetophenone Semicarbazones. The Synthesis of 1,2,3-Thiadiazoles

The reaction of thionyl chloride with a series of para-substituted acetophenone semicarbazones, which gives 1,2,3-thiadiazoles, involved an electrophilic attack.The rates correlated with the substituent ?+ constants and gave a Hammett ρ value o