82895-22-5

Upstream product

• 82895-19-0 (R)-3-Chloromethyl-2-[(2R,3R)-2-(4-nitro-benzenesulfonylsulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-but-3-enoic acid 4-nitro-benzyl ester 
• 82895-13-4 (R)-3-Methyl-2-[(2R,3R)-2-(4-nitro-benzenesulfonylsulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-but-3-enoic acid 4-nitro-benzyl ester 
• 93861-43-9 3-Methyl-2-[2-(4-nitro-benzenesulfonylsulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-but-3-enoic acid 4-nitro-benzyl ester 
• 95406-23-8 3-Chloromethyl-2-[2-(4-nitro-benzenesulfonylsulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-but-3-enoic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

PENICILLIN-CEPHALOSPORIN CONVERSION III. A NOVEL ROUTE TO 3-CHLOROMETHYL-Δ3-CEPHEMS

Synthesis of 3-chloromethyl-Δ3-cephems 3 from 4-arenesulfonylthioazetidin-2-ones 1, derived from penicillins G and V, has been achived by the electrolytic ene-type chlorination of 1 in a CHCl3-aqueous NaCl-H2SO4-(Pt electrodes) system and subse