82925-88-0

Usage

Synonyms

Tris(chloromethyl)propane

Physical state

Colorless, oily liquid

Uses

a. Crosslinking agent in epoxy resins
b. Monomer in polymer synthesis
c. Building block for pharmaceuticals and agrochemicals

Toxicity

Highly toxic

Hazards

a. Skin irritation
b. Eye irritation
c. Respiratory system irritation

Safety measures

Proper handling and storage required to minimize exposure and potential harm.

Upstream product

• 77-99-6 1,1,1-tri(hydroxymethyl)propane 
• 98-59-9 p-toluenesulfonyl chloride 
• 82925-87-9 5-chloromethyl-5-ethyl-2-thia-1,3-dioxane 2-oxide 

Downstream Products

• 101069-25-4 1,1,1-tris(diphenylphosphinomethyl)propane 
• 941697-86-5 C₆₃H₅₆N₁₀P₃Br₃ 
• 941697-84-3 C₆₃H₅₉N₁₀P₃ 

Relevant academic research and scientific papers

A flexible, convergent approach to polycyclic indole structures: Formal synthesis of (±)-mersicarpine

The formal synthesis of (±)-mersicarpine was achieved using an lntermolecular radical addition-radical cyclization cascade. This key reaction represents a flexible, convergent route to numerous polycyclic indole derivatives.

Modulating the propeller-like shape of a tripodal C(CH2PPh2)3 fragment by the size of the substituent at the pivotal carbon atom in macrobicyclic tri-λ5-phosphazenes

The chiral macrobicyclic tri-λ5-phosphazenes formed by tripod-tripod coupling of tris(3-azidobenzyl)amines and 1,1,1-tris[(diphenylphosphino)methyl]methanes present helical topologies as a result of combining two propeller-shaped tripodal fragm

New trigonal tris(phosphine oxides)

The reaction of 1,1,1-tris(chloromethyl)propane with diphenylphosphine under phase-transfer conditions afforded 1,1,1-tris(diphenylphosphinomethyl) propane, whose oxidation gave a previously unknown representative of trigonal tris(phosphine oxides), viz.,

KINETICS OF THE TRANSFORMATION OF 5-R-5-CHLOROMETHYL-2-THIA-2-OXO-1,3-DIOXANES TO 1,3-DICHLORO-2-R-2-CHLOROMETHYLPROPANES

Investigation of the kinetics of the formation of 1,3-dichloro-2-R-2-chloromethylpropanes from 5-R-5-chloromethyl-2-thia-2-oxo-1,3-dioxane by the action of an equimolecular mixture of thionyl chloride and dimethylformamide (the Vilsmeier-Haack reagent) led to the conclusion that the low activation energies and the large negative entropy values indicate the participation of a stable intermediate in the investigated complex many-stage reaction.

PRODUCTION OF CYCLIC SULFITES AND THEIR TRANSFORMATION INTO SUBSTITUTED TRI(CHLOROMETHYL)METHANES

The production of cyclic sulfites from trihydric alcohols and their conversion into chlorides by the action of DMFA-SOCl2 complex are described.By PMR and IR spectroscopy it was shown that cyclic sulfites exist preferentially in the chair conformation with the axial orientation of the S=O bond.It was established that the chlorides are formed in two parallel paths, i.e. directly from trihydric alcohols and their cyclic sulfites.