82944-13-6

Basic information

• Product Name: Benzoyl chloride, 4-chloro-2-hydroxy- (9CI)
• Synonyms: Benzoyl chloride, 4-chloro-2-hydroxy- (9CI);BENZOYL CHLORIDE, 4-CHLORO-2-HYDROXY
• CAS NO: 82944-13-6
• Molecular Formula: C₇H₄Cl₂O₂
• Molecular Weight: 191.01146
• Product Categories: ACIDHALIDE
• Mol File: 82944-13-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzoyl chloride, 4-chloro-2-hydroxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride, 4-chloro-2-hydroxy- (9CI)(82944-13-6)
• EPA Substance Registry System: Benzoyl chloride, 4-chloro-2-hydroxy- (9CI)(82944-13-6)

Safety Data

• Hazardous Substances Data: 82944-13-6(Hazardous Substances Data)

Upstream product

• 5106-98-9 4-chlorosalicylic acid 

Downstream Products

• 106841-13-8 N-benzyl-4-chloro-2-hydroxybenzamide 
• 610320-94-0 4-chloro-N-(4-methoxybenzyl)salicylamide 
• 610320-85-9 4-chloro-N-(3,4-dichlorobenzyl)salicylamide 
• 1039970-03-0 4-chloro-N-(3-fluoro-benzyl)-2-hydroxy-benzamide 
• 915380-64-2 4-chloro-N-(4-cyanobenzyl)-2-hydroxybenzamide 
• 521272-05-9 4-chloro-2-hydroxy-N-(4-(trifluoromethyl)phenyl)benzamide 
• 1415566-81-2 C₁₀H₆ClN₃O₄S 
• 1026969-83-4 C₁₂H₇Cl₂NO₃ 
• 216586-13-9 Phenyl 4-chloro-2-trifluoromethoxybenzoate 

Relevant articles and documents

Design, synthesis, and biological evaluation of 3′,4′,5′-trimethoxy evodiamine derivatives as potential antitumor agents

A series of compounds bearing 3′,4′,5′-trimethoxy module into the core structure of evodiamine were designed and synthesized. The synthesized compounds were screened in vitro for their antitumor potential. MTT results showed that compounds 14a–14c and 14i–14j had significant effects, with compound 14h being the most prominent, with an IC50 value of 3.3 ± 1.5?μM, which was lower than evodiamine and 5-Fu. Subsequent experiments further confirmed that compound 14h could inhibit cell proliferation and migration, and induce G2/M phase arrest to inhibit the proliferation of HGC-27 cells, which is consistent with the results of the cytotoxicity experiment. Besides, 14h could inhibit microtubule assembly and might kill tumor cells by inhibiting VEGF and glycolysis. All experimental results indicate that compound 14h might be a potential drug candidate for the treatment of gastric cancer and was worthy of further study.

Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents

A critical question in natural product-based drug discovery is how to translate the product into drug-like molecules with optimal pharmacological properties. The generation of natural product-inspired scaffold diversity is an effective but challenging strategy to investigate the broader chemical space and identify promising drug leads. Extending our efforts to the natural product evodiamine, a diverse library containing 11 evodiamine-inspired novel scaffolds and their derivatives were designed and synthesized. Most of them showed good to excellent antitumor activity against various human cancer cell lines. In particular, 3-chloro-10-hydroxyl thio-evodiamine (66c) showed excellent in vitro and in vivo antitumor efficacy with good tolerability and low toxicity. Antitumor mechanism and target profiling studies indicate that compound 66c is the first-in-class triple topoisomerase I/topoisomerase II/tubulin inhibitor. Overall, this study provided an effective strategy for natural product-based drug discovery. (Figure Presented).

Site-specific conversion of cysteine thiols into thiocyanate creates an IR probe for electric fields in proteins

The nitrile stretching mode of the thiocyanate moiety is a nearly ideal probe for measuring the local electric field arising from the organized environment of the interior of a protein. Nitriles were introduced into three proteins: ribonuclease S (RNase S