82954-46-9Relevant articles and documents
6-β-AMIDOPENICILLANIC ACID. A NOVEL β-LACTAMASE INHIBITOR
Mezes, Peter S.F.,Friesen, Richard W.,Viswanatha, Thamaiah,Dmitrienko, Gary I.
, p. 1207 - 1210 (2007/10/02)
Benzyl 6-β-amidopenicillanate, 4, was prepared by reaction of benzyl 6-β-aminopenicillanate, 3, with two equivalents of trifluoromethane sulfonic anhydride.In the presence of aqueous base 4 undergoes detriflation to yield 7 and in the presence of basic methanol 4 yields the α-methoxymonotriflamide 6.The free acid 5 obtained by hydrogenolysis of 4 has β-lactamase inhibitory properties.