82961-71-5Relevant articles and documents
Stereoselective synthesis of disubstituted 3(2H)-furanones via catalytic intramolecular C-H insertion reactions of α-diazo-β-keto esters including asymmetric induction
Brandes, Bridget D.
, p. 7269 - 7272 (2007/10/02)
Rhodium(II) catalysed decomposition of γ-alkoxy-α-diazo-β-ketoesters produce cis-2,5-disubstituted-3(2H) furanones with high (> 97%) stereoselectivity. The combination of a chiral auxiliary in the ester moiety of the diazo precursor and a chiral catalyst can lead to asymmetric synthesis with diastereoselectivities up to 61% de.