82982-59-0Relevant academic research and scientific papers
2-(N-SUBSTITUTED GUANIDINO)-4-HETERO-ARYLTHIAZOLE ANTIULCER AGENTS
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, (2008/06/13)
2,4-Disubstituted thiazole compounds of the formula STR1 or a pharmaceutically acceptable acid addition salt thereof wherein X is NH and Y is CH or N, orX is S and Y is CH;R 1 is certain straight or branched chain alkyl groups, (R 3) 2 C 6 H 3, or (R 3) 2 Ar(CH 2) n where n is an integer from 1 to 4, R 3 is H or certain substituent groups and Ar is phenylene, naphthalene or the residue of certain heteroaromatic groups; R 2 is H or (C 1-C 4)alkyl; or R 1 and R 2 taken together with the nitrogen atom to which they are attached form certain heterocyclic groups; and R 4 is H, (C 1-C 5)alkyl, NH 2 or CH 2 OH; a method for their use in treatment of gastric ulcers in mammals and pharmaceutical compositions containing said compounds.
2-GUANIDINO-4-HETEROARYL-THIAZOLES
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, (2008/06/13)
A series of 2-guanidino-4-heteroarylthiazoles, wherein the heteroaryl substituent is selected from thiazolyl, triazolyl, imidazolyl, and 2-alkyl, 2-amino and 2-carboxamido derivatives thereof, are disclosed. The novel compounds have activity as antisecretory agents and histamine H 2 antagonists and are useful for the treatment of gastric hyperacidity and peptic ulcers. Also disclosed are pharmaceutical compositions containing the novel compounds of this invention and a method of using the compounds in the treatment of gastric hyperacidity and peptic ulcers. Novel intermediates useful in the preparation of the novel antisecretory compounds are also described.
