83004-10-8

Usage

Uses

Used in Pharmaceutical Industry:
2-BROMO-6-(BROMOMETHYL)PYRIDINE is used as a synthetic intermediate for the development of various pharmaceutical compounds. The presence of bromine atoms on the pyridine ring allows for the creation of molecules with specific biological activities, which can be tailored for therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-BROMO-6-(BROMOMETHYL)PYRIDINE serves as a key component in the synthesis of pesticides and other crop protection agents. Its chemical properties can be leveraged to design molecules with targeted effects on pests or weeds, contributing to more effective and selective agrochemicals.
Used in Organic Synthesis:
2-BROMO-6-(BROMOMETHYL)PYRIDINE is utilized as a versatile building block in organic synthesis for creating a wide range of complex organic molecules. Its unique structure facilitates the formation of new chemical entities with potential applications in various fields, including materials science and specialty chemicals.
It is crucial to handle 2-BROMO-6-(BROMOMETHYL)PYRIDINE with appropriate safety measures due to its potential hazards and toxicity, ensuring the well-being of both the environment and the individuals involved in its synthesis and application processes.

InChI:InChI=1/C6H5Br2N/c7-4-5-2-1-3-6(8)9-5/h1-3H,4H2

Upstream product

• 33674-96-3 2-bromo-6-(hydroxymethyl)pyridine 
• 1824-81-3 2-Amino-6-methylpyridine 
• 5315-25-3 2-bromo-6-methylpyridine 

Downstream Products

• 1206455-34-6 C₁₈H₁₄Br₂N₄O₄S 
• 83004-11-9 1-(6-bromopyridin-2-yl)-N,N-dimethylmethanamine 
• 188637-63-0 (6-bromopyridin-2-yl)methanamine 
• 1187836-42-5 tert-butyl {6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}(pentyloxy)carbamate 
• 1187834-64-5 N-({6-[(E)-2-cyclohexylvinyl]pyridin-2-yl}methoxy)-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine 
• 1187846-34-9 N-{[6-(hex-1-yn-1-yl)pyridin-2-yl]methoxy}-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine 
• 1187836-43-6 6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]-N-(pentyloxy)pyridin-2-amine 
• 1187833-91-5 N-{[6-(hexyloxy)pyridin-2-yl]methoxy}-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine 
• 1187834-45-2 1-(1-methyl-1H-tetrazol-5-yl)-N-{[6-(pentylsulfanyl)pyridin-2-yl]methoxy}-1-phenylmethanimine 
• 1187834-01-0 1-(1-methyl-1H-tetrazol-5-yl)-1-phenyl-N-[(6-phenylpyridin-2-yl)methoxy]methanimine 
• 1184932-17-9 5-(1-(3-chloro-2-fluorobenzoyl)-4-((6-(1H-pyrazol-3-ylamino)pyridin-2-yl)methyl)piperidin-4-yl)-1,3,4-oxadiazol-2(3H)-one trifluoroacetate 
• 1184932-69-1 tert-butyl 4-((2-((benzyloxy)carbonyl)hydrazino)carbonyl)-4-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)piperidine-1-carboxylate 
• 1184932-73-7 5-(4-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-1-(3-chloro-2-fluorobenzoyl)piperidin-4-yl)-1,3,4-oxadiazol-2-(3H)-one 
• 1184932-59-9 ethyl 4-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-1-(3-chloro-2-fluorobenzoyl)piperidine-4-carboxylate 

Relevant academic research and scientific papers

Ruthenium complexes bearing unsymmetric CNC' pincer ligands: Molecular structures and electronic properties

Homoleptic ruthenium complexes [Ru(Ln)2]2+ bearing unsymmetric pyridine-based bis N-heterocyclic carbene (NHC) pincer ligands are synthesized and structurally characterized. These complexes feature the coexistence of a five-membered and a six-membered ruthenacycle within the same ligand framework, allowing an ideally octahedral CNHC-Ru-N Py bite angle close to 90°. In the solid state, impressive 3MLCT lifetimes of microsecond regime were detected in all of the complexes, of which [Ru(L4)2]2+, featuring four benzimidazol-2-ylidene donors, exhibited the longest values. Electronic properties of all of the ruthenium complexes are investigated by cyclic voltammetry and spectroscopic techniques. Density functional theory results were used to support the experimental observations.

Copper(II)-hydroperoxo complex induced oxidative N-dealkylation chemistry

A significant oxidative N-demethylation reaction occurs from a hydroperoxo-copper(II) species when formed within a tripodal tetradentate ligand framework possessing a pendant dimethylamine substrate. This mimics the monoxygenase activity occurring in the copper enzyme PHM. Observation of a product-based alkoxide-Cu intermediate and determination of a reaction kinetic isotope effect (kH/kD(intra) ～ 2.3) by studying the ligand-N(CH3)(CD3) substrate provide further insights. The mononuclear CuII(-OOH) entity or species derived from this can promote biomimetic reactivity and thus requires further attention in biological or synthetic mechanistic studies. Copyright

Ruthenium complexes bearing N-heterocyclic carbene based CNC and CN^CH2C’ pincer ligands: Photophysics, electrochemistry, and solar energy conversion

A combination of N-heterocyclic carbene (NHC) based CNC, or CN^CH2C′ pincer ligands and carboxy-phenyl terpyridine donors is used to prepare ruthenium complexes. The unsymmetrical coordination of CN^CH2C′ pincer

TRIAZOLOPYRIMIDINE DERIVATIVES FOR USE AS GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS

The present invention relates to compounds of general formula I, wherein the groups R1 and R2 are defined as in claim 1, which have valuable pharmacological properties, in particular bind to ghrelin O-acyl transferase (GOAT) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular obesity.

HETEROCYCLIC COMPOUND AND USE THEREOF

The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I) : wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis treatment of narcolepsy.

FUSED HETEROCYCLIC DERIVATIVES, THEIR PREPARATION METHODS THEREOF AND MEDICAL USES THEREOF

The present invention relates to fused heterocyclic derivatives, processes for their preparation and their use in medicine. Specifically, the present invention relates to a novel derivative represented by the formula (I′), or its pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the derivative or its pharmaceutically acceptable salt thereof, and the method for preparing the derivative and its pharmaceutically acceptable salt thereof. The present invention also relates to the use of the derivative and its pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing the derivative and its pharmaceutically acceptable salt thereof in the preparation of medicines, in particularly as IDO inhibitor medicines, for treating and/or preventing cancers. Wherein each substituent of the formula (I′) is the same as defined in the specification.

Tri-(2-picolyl)amine-modificated triarylborane: Synthesis, photophysical properties and distinguish for cyanide and fluoride anions in aqueous solution

We designed and synthesized a tri-(2-picolyl) amine (TPA) functionalized triarylborane, 1-(6-(4-(dimesitylboryl)phenyl)pyridin-2-yl)-N,N-bis(pyridin-2-ylmethyl)methanamine (PB2). The photophysical properties of PB2 were thoroughly explored. Moreover, PB2

2 - Bromo -6 - aldehyde pyridine and its preparation method

The present invention provides a 2 - bromo - 6 - aldehyde pyridine and its preparation, wherein the preparation method comprises the following steps: step S1, in the 2 - bromo - 6 - methyl pyridine in an organic solution to react [...], generating 2 - bromo - 6 - bromo pyridine and 2 - bromo - 6 - ([...]) pyridine mixture; step S2, adding ethanol in the mixture, and wherein add hexamine, allowing the mixture to react, to obtain 2 - bromo - 6 - formyl pyridine; step S3, after the addition of an acid in the reaction system, make it undergo hydrolytic reaction, generating the 2 - bromo - 6 - aldehyde pyridine. According to the embodiment of the invention of 2 - bromo - 6 - aldehyde pyridine of the preparation method, can obtain a high purity of the product, and the method is safe, easy to process, the process is simple, and is suitable for industrial production.

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes

INHIBITORS OF JANUS KINASES

The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3, TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.