83012-12-8Relevant academic research and scientific papers
ONE POT SYNTHESIS OF [2, 8-BIS (TRIFLUOROMETHYL)-4- QUINOLINYL]2-PYRIDINYLMETHANONE, A MEFLOQUINE INTERMEDIATE
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, (2008/06/13)
The present invention provides a simple single step process for the preparation of [2,8-bis (trifluoromethyl)-4-quinolinyl]-2 -pyridinylmethanone, comprising the step of condensing a halo-quinoline with an alpha-picolyl derivatives in the presence of a solvent, a base and a phase transfer catalyst at ?10° C. to +90° C.
A straightforward mid high yielding synthesis of mefloquine - II
Adam, Solange
, p. 7609 - 7614 (2007/10/02)
A new practical and high yielding synthesis of mefloquine (1) is described. Heteroarylation of 2-pyridylacetonitrile (2) gave the key intermediate 2-pyridyl-4-quinolylacetonitrile 4, which, on reaction with m-chloroperbenzoic acid, gave unexpectedly the cyanhydrine 5 The later, after base treatment afforded quantitatively the ketone 6.
