83015-12-7Relevant academic research and scientific papers
A straightforward entry to γ-trifluoromethylated allenamides and their synthetic applications
Guissart, Céline,Dolbois, Aymeric,Tresse, Cédric,Saint-Auret, Sarah,Evano, Gwilherm,Blanchard, Nicolas
supporting information, p. 2575 - 2580 (2016/11/11)
γ-Trifluoromethylated allenamides were obtained in good to excellent yields through a base-induced isomerization from the corresponding protected trifluoromethylated propargylic amines. This method, which simply required the treatment of the starting prop
One-point binding ligands for asymmetric gold catalysis: Phosphoramidites with a TADDOL-related but acyclic backbone
Teller, Henrik,Corbet, Matthieu,Mantilli, Luca,Gopakumar, Gopinadhanpillai,Goddard, Richard,Thiel, Walter,Fuerstner, Alois
supporting information, p. 15331 - 15342 (2012/11/07)
Readily available phosphoramidites incorporating TADDOL-related diols with an acyclic backbone turned out to be excellent ligands for asymmetric gold catalysis, allowing a number of mechanistically different transformations to be performed with good to outstanding enantioselectivities. This includes [2 + 2] and [4 + 2] cycloadditions of ene-allenes, cycloisomerizations of enynes, hydroarylation reactions with formation of indolines, as well as intramolecular hydroaminations and hydroalkoxylations of allenes. Their preparative relevance is underscored by an application to an efficient synthesis of the antidepressive drug candidate (-)-GSK 1360707. The distinctive design element of the new ligands is their acyclic dimethyl ether backbone in lieu of the (isopropylidene) acetal moiety characteristic for traditional TADDOLs. Crystallographic data in combination with computational studies allow the efficiency of the gold complexes endowed with such one-point binding ligands to be rationalized.
Photochemistry of vinclozolin in water and methanol-water solution
Schick,Moza,Hustert,Kettrup
, p. 1116 - 1122 (2007/10/03)
The photolysis of the fungicide vinclozolin in aqueous and methanol- water (50+50 by volume) solution has been examined. Irradiation at λ=254nm for 10 minutes resulted in 2 moiety takes place, and one or both the chlorine atoms are replaced by a methoxy group.
