830322-55-9Relevant academic research and scientific papers
Functional synthetic molecules and macromolecules for gene delivery
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Page/Page column 44-45, (2008/06/13)
The present invention describes a synthetic non-viral vector composition for gene therapy and the use of such compositions for in vitro, ex vivo and/or in vivo transfer of genetic material. The invention proposes a pharmaceutical composition containing 1) a non-cationic amphiphilic molecule or macromolecule and its use for delivery of nucleic acids or 2) a cationic amphiphilic molecule or macromolecule that transforms from a cationic entity to an anionic, neutral, or zwitterionic entity by a chemical, photochemical, or biological reaction and its use for delivery of nucleic acids. Moreover this invention describes the use of these non-viral vector compositions in conjunction with a surface to mediate the delivery of nucleic acids. An additional embodiment is the formation of a hydrogel with these compositions and the use of this hydrogel for the delivery of genetic material. A further embodiment of this invention is the use of a change in ionic strength for the delivery of genetic material.
Supramolecular assemblies of DNA with neutral nucleoside amphiphiles
Barthelemy, Philippe,Prata, Carla A. H.,Filocamo, Shaun F.,Immoos, Chad E.,Maynor, Benjamin W.,Hashmi, S. A. Nadeem,Lee, Stephen J.,Grinstaff, Mark W.
, p. 1261 - 1263 (2008/09/17)
A neutral uridine-based amphiphile is described which condenses plasmid DNA. AFM studies show that the three distinct structural components of the amphiphile (i.e, nucleobase, alkyl chains, and poly(ethylene glycol)) are required for the formation of DNA-
