830335-26-7Relevant academic research and scientific papers
Cyclizations of aminyl radicals generated from substoichiometric stannane
Zhai, Huimin,Wickenden, Jason G.,Sammis, Glenn M.
supporting information; experimental part, p. 3035 - 3038 (2011/02/24)
Substoichiometric amounts of tributyltin hydride were utilized in nitrogen-centered radical cyclizations onto silyl enol ethers for the formation of substituted cyclic imines
Stereoselective synthesis of substituted N-heterocycles via sequential cross metathesis-reductive cyclization
Gebauer, Julian,Dewi, Purnama,Blechert, Siegfried
, p. 43 - 46 (2007/10/03)
A diastereoselective synthesis of substituted piperidine and pyrrolidine derivatives is presented, employing a highly selective cross metathesis (CM) reaction followed by a domino reduction-cyclization process. A diastereoselective synthesis of substituted mono- and bicyclic-piperidine and pyrrolidine derivatives is presented, employing a highly selective cross metathesis (CM) reaction followed by a domino reduction-cyclization process.
New Diastereoselective Route to 2-Substituted cis-(2S,5S)- and trans-(2S,5R)-5-Alkylpyrrolidines as Indolizidine and Pyrrolizidine Scaffolds
Mota, Antonio J.,Chiaroni, Angele,Langlois, Nicole
, p. 4187 - 4198 (2007/10/03)
A new and short stereoselective route to the synthesis of enantiopure cis-2,5-disubstituted pyrrolidines as indolizidine or pyrrolizidine scaffolds has been developed. The method, which uses (S)-pyroglutamic acid as a chiral starting material, is based on the ring opening of N-protected 7-lactams by alkyl phenyl sulfone carbanions, followed by desulfonylation and reductive amination of alkyl 7-amino ketones. The diastereoselectivity depends on the substitution of the starting γ-lactams, and on the alkyl group of the phenyl sulfone. Total cis diastereoselectivity was observed in the formation of tert-butyl 5-alkylprolinates. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
