830346-43-5

Basic information

• Product Name: 2,4(1H,3H)-Pyrimidinedione, 5-(2-chloro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]meth yl]-
• CAS NO: 830346-43-5
• Molecular Formula: C19H13ClF4N2O3
• Molecular Weight: 428.77
• Mol File: 830346-43-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,4(1H,3H)-Pyrimidinedione, 5-(2-chloro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]meth yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Pyrimidinedione, 5-(2-chloro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]meth yl]-(830346-43-5)
• EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 5-(2-chloro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]meth yl]-(830346-43-5)

Safety Data

• Hazardous Substances Data: 830346-43-5(Hazardous Substances Data)

Upstream product

• 830346-42-4 5-(2-chloro-3-methoxyphenyl)pyrimidine-2,4-(1H,3H)-dione 
• 239087-08-2 2-(bromomethyl)-1-fluoro-3-(trifluoromethyl)benzene 
• 184970-25-0 1-(bromomethyl)-2-fluoro-3-(trifluoromethyl)benzene 

Downstream Products

• 830346-44-6 3-[2(R)-{tert-butoxycarbonylamino}-2-phenylethyl]-5-(2-chloro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)-benzyl]pyrimidine-2,4-(1H,3H)-dione 

Relevant articles and documents

GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO

GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein n, R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

PYRIMIDINE-2,4-DIONE DERIVATIVES AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS

GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure formula (I) wherein R1a, R1b, R2a, R2b, R3, R4, R5, R6, R7 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.