83036-34-4

Upstream product

• 83036-33-3 2-(tert-Butyl-dimethyl-silanyloxymethyl)-4-methyl-5-oxo-3-phenylsulfanyl-cyclopent-3-enecarboxylic acid methyl ester 
• 71847-75-1 methyl (E)-3-lithio-2-methyl-3-phenylthioprop-2-enoate 
• 83036-32-2 methyl (E)-4-(tert-butyldimethylsilyloxy)but-2-enoate 

Downstream Products

• 83036-36-6 4-(tert-Butyl-dimethyl-silanyloxymethyl)-2,3-dimethyl-5-phenylsulfanylmethyl-cyclopent-2-enone 
• 77871-33-1 4-Hydroxymethyl-2,3-dimethyl-5-phenylsulfanylmethyl-cyclopent-2-enone 
• 83036-35-5 4-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methyl-3-phenylsulfanyl-5-phenylsulfanylmethyl-cyclopent-2-enone 

Relevant academic research and scientific papers

SYNTHESIS OF (+/-)-DESEPOXY-4,5-DIDEHYDROMETHYLENOMYCIN A

The reaction of methyl (E)-3-lithio-2-methyl-3-phenylthioprop-2-enoate (4) with methyl (E)-4-(t-butyldimethylsilyloxy)but-2-enoate (5) provides the functionalized cyclopentenone (6) in one step, which is transformed into both Koreeda's and Smith's intermediates (2) and (3) for synthesis of (+/-)-desepoxy-4,5-didehydromethylenomycin A (1).