83049-57-4Relevant academic research and scientific papers
Efficient synthesis of 6-amino-8-aryl-2-methyl-1,2,3,4- tetrahydroisoquinoline-5,7-dicarbonitrile under solvent-free conditions
Rong, Liangce,Gao, Lijiu,Han, Hongxia,Jiang, Hong,Dai, Yisi,Tu, Shujiang
experimental part, p. 289 - 294 (2010/03/30)
A series of 6-amino-8-aryl-2-methyl-1,2,3,4-tetrahydroisoquinoline-5,7- dicarbonitriles were prepared in good yields under solvent-free conditions by multicomponent reactions of aromatic aldehyde, malononitrile, and 1-methylpiperidin-4-one in the presence of sodium hydroxide (NaOH). The structures of the products were characterized by infrared, 1H NMR spectra, elemental analysis, and high-resolution mass spectrometery (HRMS).
A SPONTANEOUS RING CLOSURE REACTION AS A NEW ROUTE TO ISOQUINOLINE DERIVATIVES
Andresen, Ole Riis,Pedersen, Erik B.
, p. 1467 - 1471 (2007/10/02)
A spontaneous reaction takes place between benzaldehydes, malononitrile and N-methyl-4-piperidone to yield the compounds 1a-i which can be aromatized to the new dicyano-1,2,3,4-tetrahydroisoquinolinamines 2a-e.Tetrahydro-2,7-naphtyridines 3a,b were also i
