83049-59-6Relevant academic research and scientific papers
Synthesis and biological evaluation of novel tetrahydroisoquinoline derivatives as antitumor agents
Wang, Dao-Cai,Song, Hang,Yao, Shun
, p. 3493 - 3495 (2014/08/05)
Fifteen novel tetrahydroisoquinoline derivatives have been synthesized via a mild synthetic route. The structures of all the compounds were confirmed by 1H NMR spectra, 13C NMR spectra and mass spectra. Their antitumor activities were evaluated in four human tumor cell lines, including human colon carcinoma (HCT116), non-small cell lung cancer (H1975), human lung adenocarcinoma (A549) and human pancreatic cancer (BxPC-3). Among them, compounds 4i and 4j exhibited remarkable growth inhibitory activity against the subtotal tested subpanel tumor cell lines particularly H1975 with GI values of 59.1 and 63.0 %, respectively.
A SPONTANEOUS RING CLOSURE REACTION AS A NEW ROUTE TO ISOQUINOLINE DERIVATIVES
Andresen, Ole Riis,Pedersen, Erik B.
, p. 1467 - 1471 (2007/10/02)
A spontaneous reaction takes place between benzaldehydes, malononitrile and N-methyl-4-piperidone to yield the compounds 1a-i which can be aromatized to the new dicyano-1,2,3,4-tetrahydroisoquinolinamines 2a-e.Tetrahydro-2,7-naphtyridines 3a,b were also i
