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Zabicipril, also known as zabicipril hydrochloride, is an angiotensin-converting enzyme (ACE) inhibitor used in the treatment of hypertension and heart failure. It functions by blocking the action of ACE, an enzyme responsible for the conversion of angiotensin I to angiotensin II, which is a potent vasoconstrictor. By inhibiting ACE, zabicipril reduces the production of angiotensin II, leading to vasodilation and a decrease in blood pressure. Additionally, it promotes the release of vasodilatory substances like bradykinin, further contributing to its blood pressure-lowering effects. Zabicipril is typically prescribed as a once-daily oral medication and is part of a class of drugs that have been shown to improve cardiovascular outcomes in patients with hypertension and certain heart conditions.

83059-56-7

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83059-56-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 83059-56-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,0,5 and 9 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 83059-56:
(7*8)+(6*3)+(5*0)+(4*5)+(3*9)+(2*5)+(1*6)=137
137 % 10 = 7
So 83059-56-7 is a valid CAS Registry Number.
InChI:InChI=1/C23H32N2O5/c1-3-30-23(29)19(14-9-16-7-5-4-6-8-16)24-15(2)21(26)25-18-12-10-17(11-13-18)20(25)22(27)28/h4-8,15,17-20,24H,3,9-14H2,1-2H3,(H,27,28)/t15-,17?,18?,19-,20-/m0/s1

83059-56-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name (3S)-2-{N-[(2S)-1-Ethoxy-1-oxo-4-phenyl-2-butanyl]-L-alanyl}-2-az abicyclo[2.2.2]octane-3-carboxylic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:83059-56-7 SDS

83059-56-7Downstream Products

83059-56-7Relevant academic research and scientific papers

Synthesis and Conformational Studies of Zabicipril (S9650-3), a Potent Inhibitor of Angiotensin Converting Enzyme

Vincent, Michel,Pascard, Claudine,Cesario, Michele,Remond, Georges,Bouchet, Jean-Paul,et al.

, p. 7369 - 7372 (1992)

The synthesis of the title compound 8c is described.This inhibitor of Angiotensin Converting Enzyme (ACE) contains aza-2 bicyclooctane-carboxylic acid, a bulky cyclic amino acid replacing the proline moiety present in most ACE inhibitors described

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