83066-68-6

Upstream product

• 598-23-2 3-methyl-but-1-yne 
• 90095-31-1 C₃₄H₅₆O₇S 
• 83066-66-4 (22R,23R,24S)-2β-acetyloxy-22,23-isopropylidene-dioxy-ergost-5-ene 
• 76976-75-5 (22R)-3β-tetrahydropyranyloxycholest-5-en-23-yn-22-ol 
• 76976-83-5 (22S)-3β-tetrahydropyranyloxycholest-5-en-23-yn-22-ol 
• 83066-59-5 (2R,3R,4R,5S)-3,4-Dihydroxy-5-((3S,8S,9S,10R,13S,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-isopropyl-hexanenitrile 
• 83066-62-0 Acetic acid (3S,8S,9S,10R,13S,14S,17R)-17-{(S)-1-[(4R,5R)-5-((S)-1-formyl-2-methyl-propyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 
• 83066-65-3 (22R,23R,24S)-3β-acetoxy-28-iodoergost-5-ene-22,23-diol 22,23-acetonide 
• 90095-30-0 (22R,23R,24S)-3β-acetoxyergost-5-ene-22,23,28-triol 22,23-acetonide 
• 83066-61-9 (22R,23R,24S)-24-formylcholest-5-ene-3β,22,23-triol 22,23-acetonide 
• 83066-60-8 (22R,23R,24S)-24-cyanocholest-5-ene-3β,22,23-triol 22,23-acetonide 
• 76976-77-7 (22R,23R,24R)-23,24-epoxy-3β-tetrahydropyranyloxycholest-5-en-22-ol 
• 76976-76-6 <22S,23(24)Z>-3β-tetrahydropyranyloxycholest-5,23-dien-22-ol 
• 22145-61-5 3β-(tetrahydropyran-2-yloxy)-23,24-dinorchol-5-en-22-al 

Downstream Products

• 87734-68-7 typhasterol 
• 80736-41-0 castasterone 
• 83066-70-0 (22R,23R,24S)-22,23-isopropylidenedioxy-6-oxo-5α-ergostan-3β-yl methanesulphonate 

Relevant academic research and scientific papers

Stereoselective Synthesis of Plant Growth-promoting Steroids, Brassinolide, Castasterone, Typhasterol, and Their 28-Nor Analogues

Plant growth-promoting steroids, brassinolide (1a), (22R,23R,24S)-2α,3α,22,23-tetrahydroxy-B-homo-7-oxa-5α-ergostan-6-one, castasterone (2a), (22R,23R,24S)-2α,3α,22,23-tetrahydroxy-5α-ergostan-6-one, 28-norbrassinolide (1b), (22R,23R)-2α,3α,22,23-tetrahydroxy-B-homo-7-oxa-5α-cholestan-6-one, brassinone (2b), (22R,23R)-2α,3α,22,23-tetrahydroxy-5α-cholestan-6-one, and typhasterol (2c), (22R,23R,24S)-3α,22,23-trihydroxy-5α-ergostan-6-one, have been stereoselectively synthesized.These steroids show very strong biological activities in three different kinds of bioassays.

A Simple Synthesis of Steroidal 3α,5-Cyclo-6-ones and their Efficient Transformation to Steroidal 2-En-6-ones

Sterols 1 were converted to 3α-5-cyclo-6-ones 4 via their mesylates and subsequent oxidation.Refluxing 4 with sodium bromide/p-toluene sulfonic acid in dimethylformamide gave steroidal 2-en-6-ones 5, among which 5 is an important brassinolide intermediate.