83066-87-9Relevant academic research and scientific papers
Synthesis, SAR, and X-ray structure of human BACE-1 inhibitors with cyclic urea derivatives
Park, Heuisul,Min, Kyeongsik,Kwak, Hyo-Shin,Koo, Ki Dong,Lim, Dongchul,Seo, Sang-Won,Choi, Jae-Ung,Platt, Bettina,Choi, Deog-Young
, p. 2900 - 2904 (2008/12/22)
We describe synthesis and evaluation of a series of cyclic urea derivatives with hydroxylethylamine isostere. Modification of P3, P1, and P2′ and combination of SAR display a >100-fold increase in potency with good cellular activity (IC50 = 0.1
2-OXOIMIDAZOLIDINE DERIVATIVES
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, (2008/06/13)
A 2-oxoimidazolidine derivative of the formula: STR1 wherein R 1 is lower alkyl or phenyl-lower alkyl and R 2 is lower alkyl or phenyl, and a process for preparation thereof are disclosed. Said 2-oxoimidazolidine derivative (I) or a pharmaceutically acceptable salt thereof is useful as a hypotensive agent.
