83067-94-1

Basic information

• Product Name: 4-Oxo-1,4-dihydro-[1,5]naphthyridine-3-carboxylic acid ethyl ester
• Synonyms: 4-Oxo-1,4-dihydro-[1,5]naphthyridine-3-carboxylic acid ethyl ester;ethyl 4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate;1,5-Naphthyridine-4-oxo-3-carboxylic acid ethyl ester
• CAS NO: 83067-94-1
• Molecular Formula: C₁₁H₁₀N₂O₃
• Molecular Weight: 218.2087
• Mol File: 83067-94-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 368.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.303±0.06 g/cm3(Predicted)
• PKA: 1.32±0.20(Predicted)
• CAS DataBase Reference: 4-Oxo-1,4-dihydro-[1,5]naphthyridine-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Oxo-1,4-dihydro-[1,5]naphthyridine-3-carboxylic acid ethyl ester(83067-94-1)
• EPA Substance Registry System: 4-Oxo-1,4-dihydro-[1,5]naphthyridine-3-carboxylic acid ethyl ester(83067-94-1)

Safety Data

• Hazardous Substances Data: 83067-94-1(Hazardous Substances Data)

Upstream product

• 462-08-8 pyridin-3-ylamine 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 14029-71-1 2-(pyridin-3-yl)aminomethylene-malonic acid diethyl ester 

Downstream Products

• 83067-95-2 4-chloro-1,5-naphthyridine-3-carboxylic acid ethyl ester 
• 1279716-19-6 ethyl 4-oxo-1-{[4-(1H-pyrazol-1-yl)phenyl]methyl}-1,4-dihydro-1,5-naphthyridine-3-carboxylate 
• 1279716-20-9 ethyl 1-{[4-(1H-pyrazol-1-yl)phenyl]methyl}-4-thioxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate 
• 1279716-21-0 5-{[4-(1H-pyrazol-1-yl)phenyl]methyl}-2,5-dihydro-3H-pyrazolo[4,3-c]-1,5-naphthyridin-3-one 
• 1279716-02-7 2-(2-fluorophenyl)-5-{[4-(1H-pyrazoI-1-yI)phenyl]methyl}-2,5-dihydro-3H-pyrazolo[4,3-c]-1,5-naphthyridin-3-one 
• 1617540-19-8 ethyl 1-((4'-chlorobiphenyl-2-yl)methyl)-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate 
• 1617540-16-5 ethyl 1-(2-(4-chlorophenylthio)benzyl)-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate 
• 1617540-17-6 1-((4'-chlorobiphenyl-2-yl)methyl)-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylic acid 
• 1617540-14-3 1-(2-(4-chlorophenylthio)benzyl)-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylic acid 
• 1345868-12-3 C₂₆H₂₂F₂N₄O₃ 
• 83068-03-5 3-Ethoxycarbonyl-4-benzylthio-1,5-naphthyridine 
• 83067-98-5 3-Ethoxycarbonyl-4-phenylamino-1,5-napthyridine 
• 83068-07-9 1H-2-Phenyl-3-oxo-2,3-dihydropyrazolo<4,3-c>-1,5-naphthyridine 
• 83068-06-8 1-Phenyl-3-hydroxypyrazolo<4,3-c>-1,5-naphthyridine 

Relevant articles and documents

NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE

The present invention relates to a compound having the general formula (V), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

Synthesis and structure-activity relationship studies of dihydronaphthyridinediones as a novel structural class of potent and selective PDE7 inhibitors

The synthesis and SAR studies of a series of structurally novel inhibitors of PDE7 are discussed. The best compounds from the series display low nanomolar inhibitory activity and are selective versus other PDE isoenzymes.