83073-63-6Relevant academic research and scientific papers
A convenient method for the preparation of 4-hydroxy-2-methyl-1-oxo-1,2- dihydroisoquinoline-3-carboxylic acid derivatives
Blanco, Maria Mercedes,Shmidt, Maria Sol,Schapira, Celia Beatriz,Perillo, Isabel Amalia
, p. 1971 - 1974 (2006)
An improved method for the synthesis of 4-hydroxy-2-methyl-1-oxo-1,2- dihydroisoquinoline-3-carboxylic acid derivatives is described. The synthetic route involves initial phthalic anhydride aminolysis with alkylaminoacetic acid derivatives, further esterification with diazomethane and final heterocyclization of the phthalamic ester intermediates by alkoxide-induced Dieckmann condensation. The best yields are reached for esters and N,N-disubstituted carboxamides. Georg Thieme Verlag Stuttgart.
