83074-75-3Relevant academic research and scientific papers
(Nitroaryl)sulfinyl-Substituted Allenes. Novel and Convenient Propargyl Alcohol Synthons in 4 + 2 Cycloaddition Chemistry
Padwa, Albert,Bullock, William H.,Norman, Bryan H.,Perumattam, John
, p. 4252 - 4259 (1991)
(Nitroaryl)sulfinyl-substituted allenes are conveniently prepared by treating propargyl alcohol or methyl 3-hydroxy-2-butynoate with a (nitroaryl)sulfenyl chloride and triethylamine.These activated allenes undergo 4 + 2 cycloaddition across the C1C2 α-bond.The initially formed allylic sulfoxide readily undergoes a 2,3-sigmatropic rearrangement to produce a stable sulfenate ester that is easily cleaved with thiophilic reagents.The dienophilic reactivity of the (nitroaryl)sulfinyl-substituted allene is much greater than the corresponding propargyl alcohol, and the cycloaddition also proceeds with high regioselectivity.The Diels-Alder reaction of propadiene with Danishefsky's diene affords meta-substituted benzyl alcohols in high yield.Reaction of the more highly activated methyl 2--2,3-butadienoate with Danishefsky's diene followed by treatment of the resulting sulfenate ester with triethyl phosphite produces substituted phthalides in excellent yield.The (2,4-dinitrophenyl)sulfinyl-substituted allene was found to react smoothly with a variety of nitrones to give sulfenate esters of isoxazolidines.These allenyl sulfoxides correspond to formal equivalents of propargyl alcohol, which itself is too unreactive to undergo Diels-Alder chemistry or 1,3-dipolar cycloaddition with nitrones or nitrile oxides.
Phosphorus- and Sulfur-substituted Allenes in Synthesis, III. - β-Keto Sulfoxides from 3-Alkyn-1-ols via Allenic Sulfoxides
Altenbach, Hans-Josef,Soicke, Hartwig
, p. 1096 - 1104 (2007/10/02)
Allenic sulfoxides 3, readily available by sigmatropic rearrangement of sulfenic esters 2 of 3-alkyn-1-ols 1, can be transformed to give β-keto sulfoxides 9 by nucleophilic addition of diethylamine and subsequent hydrolysis of the formed enamines.
