83084-58-6Relevant academic research and scientific papers
A dimethylsulfonium methylide mediated highly regioselective olefination of conjugated polyolefin 1,1-dioates to conjugated polyene-2-yl-malonates and their applications in Diels-Alder reactions
Singh, Rekha,Ghosh, Sunil K.
supporting information; experimental part, p. 2284 - 2292 (2010/06/16)
The reactions between dimethylsulfonium methylide and 1,3-diene- or 1,3,5-triene-1,1-dioates under specific conditions enable the highly regioselective tandem ylide addition-eliminative olefination to provide 1,3-butadien-2-yl- or 1,3,5-hexatriene-2-yl-malonates. Alkylation at malonate methine carbon of 1,3-butadien-2-ylmalonates with a suitable alkyl halide having in-built functionalities for a dienophile generation led to quick assembly of precursors for type 2 intramolecular Diels-Alder reaction. Syntheses of functionalized bicyclo[n.3.1] alkenes (n=5 or 6) with the double bond at the bridgehead position have been achieved via the IMDA. An asymmetric version of this reaction has been developed using a MacMillan's imidazolidinone catalyst, which provided a bicyclo[5.3.1] alkene with very high enantioselectivity. In situ methylation at malonate methine carbon of 1,3,5-hexatriene-2-yl-malonates followed by intermolecular Diels-Alder reaction with N-methylmaleimide provided the cycloadduct with complete regiocontrol and high diastereoselectivity.
"Singapore green": A new fluorescent dye for microarray and bioimaging applications
Li, Junqi,Yao, Shao Q.
supporting information; experimental part, p. 405 - 408 (2009/07/11)
(Figure Presented) We have synthesized Singapore Green (SG), a structural hybrid of Tokyo Green and Rhodamine 110. This new dye is a green light-emitting substitute for 7-aminocoumarin, a blue fluorescent dye widely used in enzymatic assays. SG-conjugated
METABOLICALLY STABLE ALKOXYALKYL ESTERS OF ANTIVIRAL OR ANTIPROLIFERATIVE PHOSPHONATES, NUCLEOSIDE PHOSPHONATES AND NUCLEOSIDE PHOSPHATES
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Page/Page column 36; 37-38, (2008/06/13)
The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
Concise synthesis of (±)-brevioxime
Nishimura, Yutaka,Kitahara, Takeshi
, p. 553 - 556 (2007/10/03)
Brevioxime (1) is a juvenile hormone (JH) biosynthesis inhibitor isolated from Penicillium brevicompactum. The synthesis of racemic brevioxime (1) was accomplished in a straightforward manner via the β-ketoamido aldehyde.
Mechanistic Studies of Diastereoselective Cyclopropanation via Homochiral Ketals. 1. Dioxolane Structural Effects
Mash, Eugene A.,Hemperly, Susan B.,Nelson, Keith A.,Heidt, Philip C.,Deusen, Shawne Van
, p. 2045 - 2055 (2007/10/02)
Compounds structurally related to 2-cyclohexen-1-one 1,4-di-O-benzyl-L-threitol ketal were prepared and subjected to the Simmons-Smith cyclopropanation.From these experiments a mechanistic model for diastereoselective cyclopropanation of common ring syste
