83084-91-7

Upstream product

• 83084-90-6 methyl 5-n-butyloxycarbonylamino-4-oxo-2-methyl-6-phenylhexanoate 
• 21307-96-0 methyl 2-methylsuccinate 
• 86157-31-5 5-Amino-2-methyl-4-oxo-6-phenyl-hexanoic acid; hydrochloride 
• 82291-53-0 5-Amino-2-methyl-4-oxo-6-phenyl-hexanoic acid methyl ester; hydrochloride 
• 59700-83-3 3-Carbomethoxybutyryl chloride 
• 83084-78-0 4-(4-Benzyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-2-methyl-4-oxo-butyric acid methyl ester 

Downstream Products

• 83450-64-0 (S)-1-(5-Butoxycarbonylamino-2-methyl-4-oxo-6-phenyl-hexanoyl)-pyrrolidine-2-carboxylic acid benzyl ester 
• 83084-93-9 5-<(n-butyloxycarbonyl)amino>-2-methyl-4-oxo-6-phenylhexanoyl-L-proline 

Relevant academic research and scientific papers

Derivatives of the potent angiotensin converting enzyme inhibotor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline: Effect of changes at positions 2 and 5 of the hexanoic acid portion

Several derivatives of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline (1) were synthesized and tested for converting enzyme inhibition activity and blood pressure lowering effects in rats. One compound, 5(S)-benzamido-2(R)-methyl-4-oxo-6-phenylhexanoyl-L-proline (2a), had an I50 against angiotensin converting enzyme of 1.0 x 10-9 M and is the most potent inhibitor prepared thus far in this class of compounds. Testing of 2a orally at 30 mg/kg for inhibition of the angiotensin I induced blood pressure increase in conscious normotensive rats gave 100% inhibition that required 143 min before the angiotensin I blood pressure response returned to 70% of the pretreatment control response. In the conscious renal hypertensive rat, 2a given orally at a dose of 3 mg/kg caused a lowering of blood pressure that reached its maximum of 40 mmHg 8 h following drug administration.