83085-97-6

Upstream product

• 83085-92-1 ethyl 4-(4'-mercapto<1,1'-biphenyl>-4-yl)-2,4-dioxobutanoate 
• 85763-19-5 S-(4'-acetyl<1,1'-biphenyl>-4-yl) N,N-dimethylcarbamate 
• 83085-89-6 O-(4'-acetyl<1,1'-biphenyl>-4-yl) N,N-dimethylthiocarbamate 
• 83085-91-0 4-acetyl-4'-mercapto<1,1'-biphenyl> 
• 13021-17-5 1-(4'-hydroxybiphenyl-4-yl)ethanone 
• 27612-42-6 3,4-dihydro-2H-1,5-benzodioxepin-3-spirooxirane 
• 83085-98-7 ethyl 4-<4'-<<(3,4-dihydro-3-hydroxy-2H-1,5-benzodioxepin-3-yl)methyl>thio><1,1'-biphenyl>-4-yl>-2,4-dioxobutanoate 

Relevant academic research and scientific papers

Inhibitors of Glycolic Acid Oxidase. 4-Substituted 2,4-Dioxobutanoic Acid Derivatives

Fourteen new 4-substituted 2,4-dioxobutanoic acids have been synthesized.These compounds, all of which contain lipophilic 4-substituents, are potent inhibitors in vitro of porcine liver glycolic acid oxidase.The I50 value of the two most potent representatives, 4-(4'-bromo-4-yl)-2,4-dioxobutanoic acid (8) and 4-thio>-4-yl>-2,4-dioxobutanoic acid (13) is 6 * 10-8 M.

2,4-Dioxo-4-substituted-1-butanoic acid derivatives useful in treating urinary tract calcium oxalate lithiasis

2,4-Dioxo-4-substituted-1-butanoic acid derivatives of the formula: STR1 where R is hydrogen or C1-4 alkyl; and L is a lipophilic group consisting essentially of (1) STR2 where R' is (a) hydrogen; (b) C1-3 alkyl; (c) benzyl; (d) pyri