83088-99-7Relevant academic research and scientific papers
Isatin analogs as novel inhibitors of Candida spp. β-carbonic anhydrase enzymes
Akdemir, Atilla,Güzel-Akdemir, ?zlen,Karali, Nilgün,Supuran, Claudiu T.
, p. 1648 - 1652 (2016)
Enzyme inhibition data of structurally novel isatin-containing sulfonamides were determined for two carbonic anhydrases (CAs, EC 4.2.1.1) from pathogenic Candida species (CaNce103 from C. albicans and CgNce103 from C. glabrata). The compounds show KI
Synthesis of sulfonamide based chemosensor for sensing of toxic Hg2+ ions in soil extract
Ekta,Singh, Kamaljit,Utreja, Divya
, (2022/01/15)
Schiff base (3) was synthesized through single step condensation of sulfanilamide and isatin and characterized with 1H NMR, 13C NMR, FT-IR and mass spectrometry analysis. The probe (3) was evaluated as the fluorometric and colorimetr
Synthesis and selective inhibitory effects of some 2-oxindole benzenesulfonamide conjugates on human carbonic anhydrase isoforms CA I, CA II, CA IX and CAXII
George, Riham F.,Said, Mona F.,Bua, Silvia,Supuran, Claudiu T.
, (2020/01/02)
Three series of 2-oxindole benzenesulfonamide conjugates with different linkers were prepared by the condensation reaction of isatin derivatives 1a-e with different benzenesulfonamides. They were screened for their ability to inhibit human (h) carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA I, hCA II, hCA IX and hCA XII. Many compounds revealed promising activity and selectivity toward CAI, CAII and CAIX compared to acetazolamide (AAZ) especially compounds 2b (KI = 97.6, 8.0 nM against hCA I, hCA II, respectively) and 3a (KI = 90.2, 6.5 and 21.4 nM against hCA I, hCA II and hCA IX, respectively) relative to AAZ (KI = 250, 12 and 25 nM). Additionally, compound 4a revealed the highest activity against hCA II and hCA IX with KI of 3.0 and 13.9 nM, respectively. Docking of 2b, 3a and 4a into the active site of CA I, II, IX and XII revealed binding mode comparable to AAZ confirming the inhibition results.
Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII
Güzel-Akdemir, ?zlen,Akdemir, Atilla,Karali, Nilgün,Supuran, Claudiu T.
, p. 6493 - 6499 (2015/06/16)
A series of 2/3/4-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)amino]benzenesulfonamides, obtained from substituted isatins and 2-, 3- or 4-aminobenzenesulfonamide, showed low nanomolar inhibitory activity against the tumor associated carbonic anhydrase (CA, EC
Cytotoxicity of novel sulfanilamides towards sensitive and multidrugresistant leukemia cells
AlSalim,Saeed,Hadi,Zeino,Gany,Kadioglu,Titinchi,Abbo,Efferth
, p. 2715 - 2725 (2014/07/21)
Novel sulfa Schiff bases were synthesized and characterized by a reaction between aromatic sulfonamides and aromatic aldehydes or heterocyclic ketones in equimolar ratios. Their cytotoxicity was evaluated by the resazurin assay towards human sensitive CCR
