83089-65-0Relevant academic research and scientific papers
The Chemistry of 4-Mercaptoazetidin-2-ones. Part 3. Synthesis of 6-Phenoxyacetamido-2-alkylidenepenam-3-carboxylic Acids
Osborne, Neal F.
, p. 1429 - 1434 (2007/10/02)
A general method for the preparation of α-bromoallenic esters (2) involving the reaction of an acid chloride with a carboxybromomethylenetriphenylphosphorane has been developed.Reaction of these esters with the 4-mercaptoazetidin-2-one (1) gave rise to the 2-alkylidenepenam esters (3).The title compounds, obtained by hydrogenolysis of the corresponding benzyl esters, showed only moderate antibacterial properties.
