83090-45-3

Upstream product

• 85151-17-3 4-[(2-Chloro-acetylamino)-methyl]-4-hydroxy-piperidine-1-carboxylic acid benzyl ester 

Downstream Products

• 84243-24-3 3-Oxo-1-oxa-4,9-diaza-spiro[5.5]undecane-9-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Antihypertensive 9-substituted 1-oxa-4,9-diazaspiro[5.5]undecan-3-ones

Forty-one 9-substituted 1-oxa-4,9-diazaspiro[5.5]undecan-3-ones were prepared for antihypertensive screening in the spontaneously hypertensive rat (SHR). For the 9-(2-indol-3-ylethyl) series, the parent compound 9-(2-indol-3-ylethyl)-1-oxa-4,9-diazaspiro[

9-[2-(3-Indolyl)ethyl]-1oxa-4,9-diazaspiro[5.5]undecan-3-ones

Compounds useful in the prevention and/or treatment of hypertension, congestive heart failure, arrhythmia, migraine, vasospastic disorders, and asthma are represented by the formula STR1 wherein: R, R1, R2, R3, and R4 are independently hydrogen or lower alkyl of one to four carbon atoms; and R5 and R6 are independently hydrogen, lower alkyl of one to four carbon atoms or lower alkoxy of one to four carbon atoms; and the pharmaceutically acceptable acid addition salts thereof.