83101-12-6

Basic information

• Product Name: 4-(3-HYDROXY-PROPYL)-BENZONITRILE
• Synonyms: 4-(3-HYDROXY-PROPYL)-BENZONITRILE
• CAS NO: 83101-12-6
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.20044
• Mol File: 83101-12-6.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 323.691 °C at 760 mmHg
• Flash Point: 149.563 °C
• Appearance: /
• Density: 1.098 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(3-HYDROXY-PROPYL)-BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-HYDROXY-PROPYL)-BENZONITRILE(83101-12-6)
• EPA Substance Registry System: 4-(3-HYDROXY-PROPYL)-BENZONITRILE(83101-12-6)

Safety Data

• Hazardous Substances Data: 83101-12-6(Hazardous Substances Data)

Usage

General Description

4-(3-Hydroxy-propyl)-benzonitrile is a chemical compound with the molecular formula C10H11NO. It is commonly used as an intermediate in the production of pharmaceuticals, pesticides, and other organic compounds. The compound contains a benzene ring with a nitrile group and a hydroxypropyl substituent, providing it with distinctive chemical and physical properties. It is a colorless to pale yellow liquid with a faint odor and is soluble in organic solvents but insoluble in water. 4-(3-Hydroxy-propyl)-benzonitrile is utilized in various chemical reactions and synthesis processes due to its versatile reactivity and functional groups, making it a valuable compound in the chemical industry.

InChI:InChI=1/C10H11NO/c11-8-10-5-3-9(4-6-10)2-1-7-12/h3-6,12H,1-2,7H2

Upstream product

• 75567-85-0 3-(p-Cyanophenyl)-propansaeuremethylester 
• 105-07-7 4-cyanobenzaldehyde 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 3959-07-7 4-Bromobenzylamine 
• 81121-62-2 p-(3-hydroxypropyl)-benzaldehyde 
• 1122-91-4 4-bromo-benzaldehyde 
• 38628-53-4 3-<4-(hydroxymethyl)phenyl>propanol 
• 80151-10-6 4-(3-hydroxy-1-propyn-1-yl)-benzaldehyde 
• 153171-22-3 2-(4-bromobenzyl)-1H-isoindole-1,3(2H)-dione 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 80151-16-2 3-(4-cyanophenyl)-2-propyne-1-ol 
• 116460-89-0 3-(4-cyano-phenyl)-propionic acid ethyl ester 
• 1734-79-8 3-(4-nitrophenyl)-2-propenal 
• 35271-56-8 3-(4-nitrophenyl)propyl-2-en-1-ol 

Downstream Products

• 91574-48-0 3-(4-Cyanophenyl)propyl methanesulfonate 
• 3435-51-6 4-ethenylbenzonitrile 
• 1206635-01-9 4-(3-hydroxypropyl)benzylamine 
• 136295-53-9 3-(p-cyanophenyl)propionaldehyde 
• 83101-88-6 5-(4-Carbamimidoyl-phenyl)-2-(naphthalene-1-sulfonylamino)-pentanoic acid phenylamide; hydriodide 
• 83101-83-1 5-(4-Carbamimidoyl-phenyl)-2-(toluene-4-sulfonylamino)-pentanoic acid phenylamide; hydriodide 
• 83101-81-9 4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-benzamidine; hydriodide 
• 83101-82-0 5-(4-Carbamimidoyl-phenyl)-2-(toluene-4-sulfonylamino)-pentanoic acid butylamide; hydriodide 
• 83101-77-3 4-[4-(Naphthalene-2-sulfonylamino)-5-oxo-5-piperidin-1-yl-pentyl]-thiobenzimidic acid methyl ester; hydriodide 
• 83101-78-4 4-[4-Butylcarbamoyl-4-(naphthalene-2-sulfonylamino)-butyl]-thiobenzimidic acid methyl ester; hydriodide 
• 83101-73-9 4-[4-(Naphthalene-1-sulfonylamino)-5-oxo-5-piperidin-1-yl-pentyl]-thiobenzimidic acid methyl ester; hydriodide 
• 83101-79-5 4-[4-(Naphthalene-2-sulfonylamino)-4-phenylcarbamoyl-butyl]-thiobenzimidic acid methyl ester; hydriodide 
• 83101-75-1 4-[4-(Naphthalene-1-sulfonylamino)-4-phenylcarbamoyl-butyl]-thiobenzimidic acid methyl ester; hydriodide 
• 83101-74-0 4-[4-Butylcarbamoyl-4-(naphthalene-1-sulfonylamino)-butyl]-thiobenzimidic acid methyl ester; hydriodide 

Relevant articles and documents

Nitrile Synthesis by Aerobic Oxidation of Primary Amines and in situ Generated Imines from Aldehydes and Ammonium Salt with Grubbs Catalyst

Herein, a Grubbs-catalyzed route for the synthesis of nitriles via the aerobic oxidation of primary amines is reported. This reaction accommodates a variety of substrates, including simple primary amines, sterically hindered β,β-disubstituted amines, allylamine, benzylamines, and α-amino esters. Reaction compatibility with various functionalities is also noted, particularly with alkenes, alkynes, halogens, esters, silyl ethers, and free hydroxyl groups. The nitriles were also synthesized via the oxidation of imines generated from aldehydes and NH4OAc in situ. (Figure presented.).

AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF

Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of, for example, bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof. wherein each symbol is as defined in the specification.

Small, potent, and selective diaryl phosphonate inhibitors for urokinase-type plasminogen activator with in vivo antimetastatic properties

A set of small nonpeptidic diaryl phosphonate inhibitors was prepared. Some of these inhibitors show potent and highly selective irreversible uPA inhibition. The biochemical and modeling data prove that the combination of a benzylguanidine moiety with a d