83104-87-4

Usage

Uses

Used in Pharmaceutical Industry:
(-)-EGCG-3''-O-ME is used as an active ingredient for the development of anti-coronavirus drugs. Its antiviral properties make it a potential candidate for treating and preventing coronavirus infections.
Used in Healthcare Research:
(-)-EGCG-3''-O-ME is used as a research tool to investigate the mechanisms of the ameliorative effect of green tea polyphenols on diabetic neuropathy. Specifically, it helps in understanding the role of diacylglycerol kinase a in the neuroprotective effects of green tea polyphenols, which could lead to the development of novel therapeutic strategies for diabetic neuropathy treatment.

Upstream product

• 2596-50-1 (-)-epigallocathechin gallate 
• 74-88-4 methyl iodide 
• 70845-74-8 3,4-bis(benzyloxy)-5-methoxybenzoyl chloride 
• 70845-73-7 3,4-bis(benzyloxy)-5-methoxybenzoic acid 
• 901125-31-3 (-)-(2R,3R)-cis-5,7-bis(benzyloxy)-2-[3',4',5'-tris(benzyloxy)-phenyl]chroman-3-yl 3'',4''-dibenzyloxy-5''-methoxybenzoate 
• 1186527-12-7 5-(2R,3R)-5,7-bis(2-nitrophenylsulfonyloxy)-2-(3,4,5-tris(2-nitrophenylsulfonyloxy)phenyl)chroman-3-yl 3-methoxy-4,5-bis(2-nitrophenylsulfonyloxy)benzoate 
• 14031-35-7 S-Adenosyl-L-methionine 

Downstream Products

• 951755-38-7 theaflavin 3-O-(3-O-methyl)gallate 
• 951775-29-4 theaflavin 3-O-(3-O-methyl)gallate-3'-gallate 

Relevant academic research and scientific papers

A water-soluble enhancer, a method for improving the water soluble, and, a method for preparing aq.

PROBLEM TO BE SOLVED: To provide a water solubility enhancer, a water solubility enhancement method, and an aqueous solution preparation method.SOLUTION: 4"Me-EGCg, 4"Me-GCg, 4"Et-EGCg, or 4"Et-GCg is used as a water solubility enhancer for enhancing solu

Syntheses of methylated catechins and theaflavins using 2-nitrobenzenesulfonyl group to protect and deactivate phenol

An efficient and versatile synthetic method for labile polyphenols was established using 2-nitrobenzenesulfonate (Ns) as a protecting group for phenol. This methodology provides regio-and stereoselective access to a range of methylated catechins, such as methylated epigallocatechin gallates, that are not readily available from natural sources. In addition, biomimetic synthesis of theaflavins from catechins was accomplished using Ns protection to minimize undesired side reactions of electron-rich aromatic rings during oxidation, enabling construction of the complex benzotropolone core in a single-step oxidative coupling reaction. Availability of these compounds will aid detailed structure-biological activity relationship studies of catechins.

Purification and characterization of a novel O-methyltransferase from Flammulina velutipes

An enzyme catalyzing the methylation of phenolic hydroxyl groups in polyphenols was identified from mycelial cultures of edible mushrooms to synthesize O-methylated polyphenols. Enzyme activity was measured to assess whether methyl groups were introduced

Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzenesulfonyl (Ns) protecting group

Regioselective synthesis of methylated epigallocatechin gallate from epigallocatechin was accomplished using a 2-nitrobenzenesulfonyl (Ns) group as a protecting group for phenols. This methodology provided several methylated catechins, which are naturally

Regiospecific and enantioselective synthesis of methylated metabolites of tea catechins

The regiospecific and enantioselective syntheses of various methylated regioisomers of epicatechin gallate (EGC) and epigallocatechin gallate (EGCG) have been achieved.