83110-00-3

Upstream product

• 5076-63-1 (4-chlorophenyl)diethyl phosphate 
• 108-18-9 diisopropylamine 
• 106-48-9 4-chloro-phenol 
• 762-04-9 phosphonic acid diethyl ester 

Downstream Products

• 639516-89-5 4-chloro-2-(diethoxyphosphonyl)phenyl 1,1,2,2-tetra-fluoro-2-(1,1,2,2-tetrafluoroethoxy)ethanesulfonate 
• 1227161-30-9 C₁₄H₁₃ClF₉O₆PS 
• 639517-09-2 [5-chloro-2-(4-nitrophenylethynyl)phenyl]phosphonic acid monoethyl ester 
• 639517-08-1 [5-chloro-2-(4-ethylphenylethynyl)phenyl]phosphonic acid monoethyl ester 
• 639517-20-7 7-chloro-1-ethoxy-3-(4-ethylphenyl)benzo[c][1,2]oxaphosphinine 1-oxide 
• 639517-06-9 (5-chloro-2-hex-1-ynylphenyl)phosphonic acid monoethyl ester 
• 639516-97-5 [5-chloro-2-(4-nitro-phenylethynyl)-phenyl]phosphonic acid diethyl ester 
• 639516-96-4 [5-chloro-2-(4-ethyl-phenylethynyl)-phenyl]-phosphonic acid diethyl ester 
• 639516-94-2 (5-chloro-2-hex-1-ynyl-phenyl)-phosphonic acid diethyl ester 
• 639517-00-3 (5-chloro-2-trimethylsilanylethynyl-phenyl)-phosphonic acid diethyl ester 
• 639517-01-4 (5-chloro-2-cyclopropylethynyl-phenyl)-phosphonic acid diethyl ester 
• 639516-99-7 [5-chloro-2-(3-methoxy-prop-1-ynyl)-phenyl]-phosphonic acid diethyl ester 
• 639516-98-6 [5-chloro-2-(3-hydroxy-prop-1-ynyl)-phenyl]-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Enantioselective and Regioselective Hydroetherification of Alkynes by Gold-Catalyzed Desymmetrization of Prochiral Phenols with P-Stereogenic Centers

The gold(I)-catalyzed enantioselective hydroetherification of alkynes was achieved via desymmetrization of prochiral bisphenols bearing P-stereogenic centers. (S)-DTBM-Segphos(AuCl)2/AgNTf2 proved to be a highly efficient catalyst system for this transformation, affording P-chiral cyclic phosphine oxides in good yields with high enantioselectivities (with up to 99% ee). The same catalyst system allowed for the enantioselective desymmetrization of dialkynes. Synthetic transformations of the cyclization products afforded other P-chiral molecules with high enantiospecificity.

Phosphaisocoumarins as a new class of potent inhibitors for pancreatic cholesterol esterase

Due to the importance of pancreatic cholesterol esterase (CEase) as a potential target in atherosclerosis and for the development of hypocholesterolemic agents, there are increasing interests in designing and synthesizing CEase inhibitors. In the present study, we prepared forty-five isocoumarin phosphorus analogues (i.e., phosphaisocoumarins) and investigated the inhibition of these compounds on the CEase. The results showed that some phosphaisocoumarins could act as potent inhibitors of CEase. The most potent inhibitors, compounds 9d, 10a and 12e give IC50 values of 4.8?μM, 2.3?μM and 1.9?μM, respectively. The inhibition mechanism and kinetic characterization studies indicate that they are reversible competitive inhibitors.

Novel phosphorus-containing derivatives

A compound of the Formula I a prodrug thereof, or the pharmaceutically acceptable salt of the compound or prodrug; wherein X, Y, a, b, c, d, R1, R2, R3, R4, R5, R6 and R7 are as defined above and are useful to treat inflammation and other immune disorders. The present invention also relates to pharmaceutical compositions that include compounds of Formula I and a pharmaceutically acceptable carrier. Moreover, the present invention relates to methods of using the above-described compounds and compositions to treat and prevent diseases and conditions.

1,3-CARBANIONISCHE UMLAGERUNGEN: REAKTIONEN VON PHOSPHORSAEURE-o-HALOARYLESTERN MIT METALLEN ZU ARYLPHOSPHONSAEUREDERIVATEN

o-Bromoaryl esters of phosphoric acid react with magnesium to give arene phosphonic acid derivatives via intermediate Grignard compounds.Similar metallation rearrangement processes may be achieved in the case of o-chloroaryl esters if sodium is applied as

Chemistry of the Podocarpaceae. LXI. The Rearrangement of Aryl Phosphates to ortho-Hydroxyaryl Phosphanates

Treatment of methyl 12-(diethoxyphosphoryloxy)podocarpa-8,11,13-trien-19-oate (14) or its 13-bromo derivative (7) with butyllithium effects a rearrangement of the phosphate group to give methyl 13-diethoxyphosphoryl-12-hydroxypodocarpa-8,11,13-trien-19-oa