83115-56-4Relevant articles and documents
Synthesis of Naphthoquinone Antibiotics: Conjugate Addition/Electrophile Trapping with Acylnickel Carbonylate Anions
Semmelhack, M. F.,Keller, Leonard,Sato, Tadahisa,Spiess, E.
, p. 4382 - 4384 (1982)
Conjugate addition of nickel acylate complexes followed by quenching with allyl iodide provide key intermediates for the synthesis of nanomycin A and frenolicin
Conjugate Addition of Acylate-Nickel Complexes to Quinone Monoketals: Formal Synthesis of the Naphthoquinone Antibiotics Nanaomycin A and Deoxyfrenolicin
Semmelhack, M. F.,Keller, L.,Sato, T.,Spiess, E. J.,Wulff, W.
, p. 5566 - 5574 (2007/10/02)
A direct approach to the synthesis of isochromanone antibiotics such as nanaomycin A (2) and deoxyfrenolicin (3) is the conjugate addition of a carbonyl anion equivalent to the appropriate naphthoquinone monoketal followed by trapping with an allylic hali