831220-45-2Relevant academic research and scientific papers
The synthesis of bromo and iodo trifunctionalised tribenzosilatranes
Alvarez, Rubén,Mehl, Georg H.
, p. 67 - 68 (2007/10/03)
A reliable synthetic route towards selective derivatisation at the 6′,6″ and 6? positions of tribenzosilatranes with bromo or iodo groups has been developed. As these groups can be reacted further, this extends the chemistry associated with tribenzosilatranes. In this report we present a direct synthesis of bromo 8 and iodo 9 trisubstituted tribenzosilatranes. Commercially available o-anisidine 1 was transformed into the triarylamine 3 in a two-step sequence, which was halogenated to furnish the tribromo 4 or the triiodo 5 substituted triamines, respectively. Subsequent deprotection of the methyl ethers furnished the novel tripod ligands 6 and 7. A transilylation reaction in the last step led to the synthesis of the desired para-halogenated tribenzosilatranes 8 and 9.
